FOXL2
Information FOXL2
- Description
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. Is a regulator of CYP19 expression. Is a transcriptional repressor of STAR. Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element. {ECO:0000269|PubMed:15059956, ECO:0000269|PubMed:15944199, ECO:0000269|PubMed:19106105, ECO:0000269|PubMed:19797124, ECO:0000269|PubMed:20005806}.(Source UnitProtKB).
- Full Name
forkhead box L2
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 3
- Biotypes
- 1
- Peaks
- 105,470
- Non-redundant peaks
- 89,157
TF Classification
- Familly
- Fork head / winged helix factors
- Sub Familly
- Forkhead box (FOX) factors
Source JASPAR
External IDs
- NCBI Gene
- 26927
- Official Gene Name
- Foxl2
- JASPAR
- MA1607.1
- MGI
- MGI:1349428
- Ensembl
- ENSMUSG00000050397
- UniProt
- O88470
- Genevisible
- O88470
- RefSeq
- Aliases
- AU045128; BPES; PINTO; Pfrk
Datasets Table for FOXL2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| FOXL2 | ovary | GEO | Mus musculus | GSE110093 | 28,901 | |||
| FOXL2 | ovary | GEO | Mus musculus | GSE60858 | 16,152 | |||
| FOXL2 | ovary | GEO | Mus musculus | GSE62545 | 60,417 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |