FOXO1-PAX3
Information FOXO1-PAX3
- Description
Fusion of Forkhead box protein O1 and PAX3. Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC1 and PCK1. (Source UniProtKB).
- Full Name
Fusion of FOXO1 and PAX3
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 2
- Biotypes
- 1
- Peaks
- 61,491
- Non-redundant peaks
- 52,317
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
Datasets Table for FOXO1-PAX3
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| FOXO1-PAX3 | RH4 | Entinostat-6H | GEO | Homo sapiens | GSE116344 | 28,902 | ||
| FOXO1-PAX3 | RH4 | DMSO-6H | GEO | Homo sapiens | GSE116344 | 32,589 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |