FOXO3
Information FOXO3
- Description
Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:18054316, PubMed:18054315, PubMed:23805378). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (PubMed:18054316, PubMed:18054315, PubMed:25402684). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (By similarity). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (By similarity). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (PubMed:32103177). {ECO:0000250|UniProtKB:O43524, ECO:0000269|PubMed:18054315, ECO:0000269|PubMed:18054316, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:25402684, ECO:0000269|PubMed:32103177}.(Source UnitProtKB).
- Full Name
forkhead box O3
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 2
- Biotypes
- 2
- Peaks
- 83,919
- Non-redundant peaks
- 76,246
TF Classification
- Familly
- Fork head / winged helix factors
- Sub Familly
- Forkhead box (FOX) factors
Source JASPAR
External IDs
- NCBI Gene
- 56484
- Official Gene Name
- Foxo3
- JASPAR
- MA0157.1
- MGI
- MGI:1890081
- Ensembl
- ENSMUSG00000048756
- UniProt
- Q9WVH4
- Genevisible
- Q9WVH4
- RefSeq
- NM_019740
- Aliases
- 1110048B16Rik; 2010203A17Rik; FKHRL1; Fkhr2; Foxo3a
Datasets Table for FOXO3
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
FOXO3 | C2C12 | DM-72H | GEO | Mus musculus | GSE99207 | 46,339 | ||
FOXO3 | neural-progenitor | GEO | Mus musculus | GSE48336 | 37,580 | |||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |