FOXO3

Information FOXO3

Description

Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:18054316, PubMed:18054315, PubMed:23805378). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (PubMed:18054316, PubMed:18054315, PubMed:25402684). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (By similarity). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (By similarity). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (PubMed:32103177). {ECO:0000250|UniProtKB:O43524, ECO:0000269|PubMed:18054315, ECO:0000269|PubMed:18054316, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:25402684, ECO:0000269|PubMed:32103177}.(Source UnitProtKB).

Full Name

forkhead box O3

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
2
Biotypes
2
Peaks
83,919
Non-redundant peaks
76,246

TF Classification

Familly
Fork head / winged helix factors
Sub Familly
Forkhead box (FOX) factors

Source JASPAR

External IDs

NCBI Gene
56484
Official Gene Name
Foxo3
JASPAR
MA0157.1
MGI
MGI:1890081
Ensembl
ENSMUSG00000048756
UniProt
Q9WVH4
Genevisible
Q9WVH4
RefSeq
NM_019740
Aliases
1110048B16Rik; 2010203A17Rik; FKHRL1; Fkhr2; Foxo3a
All peaks FOXO3
Download BED file
Non redundant peaks FOXO3
Download BED file
SEQUENCES FOXO3
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for FOXO3

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
FOXO3 C2C12 DM-72H GEO Mus musculus GSE99207 46,339
FOXO3 neural-progenitor GEO Mus musculus GSE48336 37,580
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks