GATA4

Information GATA4

Description

Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (By similarity). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (PubMed:9584153). Promotes cardiac myocyte enlargement (By similarity). Required during testicular development (By similarity). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (By similarity). {ECO:0000250|UniProtKB:P43694, ECO:0000250|UniProtKB:P46152, ECO:0000269|PubMed:9584153}.(Source UnitProtKB).

Full Name

GATA binding protein 4

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
12
Biotypes
6
Peaks
308,509
Non-redundant peaks
164,532

TF Classification

Familly
Other C4 zinc finger-type factors
Sub Familly
GATA-type zinc fingers

Source JASPAR

External IDs

NCBI Gene
14463
Official Gene Name
Gata4
JASPAR
MA0482.1
MGI
MGI:95664
Ensembl
ENSMUSG00000021944
UniProt
Q08369
Genevisible
Q08369
RefSeq
NM_008092
Aliases
Gata-4
All peaks GATA4
Download BED file
Non redundant peaks GATA4
Download BED file
SEQUENCES GATA4
Download FASTA file
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Datasets Table for GATA4

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
GATA4 liver GEO Mus musculus GSE49131 45,845
GATA4 MEF D0 GEO Mus musculus GSE112315 11,943
GATA4 ventricle GEO Mus musculus GSE112315 13,917
GATA4 mESC d5 GEO Mus musculus GSE116258 10,085
GATA4 heart Banding GEO Mus musculus GSE52123 1,899
GATA4 heart ab GEO Mus musculus GSE52123 10,050
GATA4 heart neonatal GEO Mus musculus GSE131327 66,935
GATA4 heart Sham GEO Mus musculus GSE52123 852
GATA4 heart ab_E12-5 GEO Mus musculus GSE52123 47,968
GATA4 heart GEO Mus musculus GSE52123 29,261
GATA4 HL-1 GEO Mus musculus GSE21529 23,894
GATA4 liver ENCODE Mus musculus ENCSR194GNY 45,860
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks