GATA4
Information GATA4
- Description
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (By similarity). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (PubMed:9584153). Promotes cardiac myocyte enlargement (By similarity). Required during testicular development (By similarity). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, sphingosine-1-phosphate lyase (By similarity). {ECO:0000250|UniProtKB:P43694, ECO:0000250|UniProtKB:P46152, ECO:0000269|PubMed:9584153}.(Source UnitProtKB).
- Full Name
GATA binding protein 4
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 12
- Biotypes
- 6
- Peaks
- 308,509
- Non-redundant peaks
- 164,532
TF Classification
- Familly
- Other C4 zinc finger-type factors
- Sub Familly
- GATA-type zinc fingers
Source JASPAR
Datasets Table for GATA4
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
GATA4 | liver | GEO | Mus musculus | GSE49131 | 45,845 | |||
GATA4 | MEF | D0 | GEO | Mus musculus | GSE112315 | 11,943 | ||
GATA4 | ventricle | GEO | Mus musculus | GSE112315 | 13,917 | |||
GATA4 | mESC | d5 | GEO | Mus musculus | GSE116258 | 10,085 | ||
GATA4 | heart | Banding | GEO | Mus musculus | GSE52123 | 1,899 | ||
GATA4 | heart | ab | GEO | Mus musculus | GSE52123 | 10,050 | ||
GATA4 | heart | neonatal | GEO | Mus musculus | GSE131327 | 66,935 | ||
GATA4 | heart | Sham | GEO | Mus musculus | GSE52123 | 852 | ||
GATA4 | heart | ab_E12-5 | GEO | Mus musculus | GSE52123 | 47,968 | ||
GATA4 | heart | GEO | Mus musculus | GSE52123 | 29,261 | |||
GATA4 | HL-1 | GEO | Mus musculus | GSE21529 | 23,894 | |||
GATA4 | liver | ENCODE | Mus musculus | ENCSR194GNY | 45,860 | |||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |