GFI1

Information GFI1

Description

Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells. {ECO:0000269|PubMed:12441305, ECO:0000269|PubMed:17197705, ECO:0000269|PubMed:17707228, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:8622900}.

Full Name

growth factor independent 1 transcription repressor

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
8
Biotypes
7
Peaks
184,560
Non-redundant peaks
125,957

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
14581
Official Gene Name
Gfi1
JASPAR
MGI
MGI:103170
Ensembl
ENSMUSG00000029275
UniProt
P70338
Genevisible
P70338
RefSeq
NM_010278
Aliases
AW495828; Gfi-1; Pal-1; Pal1
All peaks GFI1
Download BED file
Non redundant peaks GFI1
Download BED file
SEQUENCES GFI1
Download FASTA file
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Datasets Table for GFI1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
GFI1 spleen GEO Mus musculus GSE103255 36,904
GFI1 medulloblastoma GEO Mus musculus GSE123870 32,808
GFI1 lymphocyte GEO Mus musculus GSE50806 54,617
GFI1 bone-marrow GEO Mus musculus GSE42518 10,306
GFI1 CD4 GEO Mus musculus GSE70893 11,066
GFI1 CD4 KO GEO Mus musculus GSE70893 5,819
GFI1 hematopoietic-progenitor GEO Mus musculus GSE84328 22,513
GFI1 granulocyte-macrophage-progenitor GEO Mus musculus GSE70237 10,527
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks