GLIS2

Information GLIS2

Description

This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.[provided by RefSeq, Jan 2010]

Full Name

GLIS family zinc finger 2

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
3
Biotypes
2
Peaks
85,631
Non-redundant peaks
58,061

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
84662
Official Gene Name
GLIS2
JASPAR
MA0736
Ensembl
ENSG00000274636
UniProt
Q9BZE0
Genevisible
Q9BZE0
RefSeq
NM_001318918
Aliases
NPHP7
All peaks GLIS2
Download BED file
Non redundant peaks GLIS2
Download BED file
SEQUENCES GLIS2
Download FASTA file
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Datasets Table for GLIS2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
GLIS2 HEK293 ENCODE Homo sapiens ENCSR535DIA 48,063
GLIS2 HCT-116 5FU GEO Homo sapiens GSE125927 21,688
GLIS2 HCT-116 DMSO GEO Homo sapiens GSE125927 15,880
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks