GPS2

Information GPS2

Description

Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'-linked ubiquitination (PubMed:22424771, PubMed:24953653, PubMed:28039360, PubMed:28123943, PubMed:29499132). In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context (PubMed:18218630, PubMed:24953653, PubMed:25519902, PubMed:27270589, PubMed:28039360). Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation (PubMed:22666460, PubMed:24953653). Promotes cholesterol efflux by acting as a transcription coactivator (By similarity). Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways (PubMed:28039360). Acts as a key mediator of mitochondrial stress response: in response to mitochondrial depolarization, relocates from the mitochondria to the nucleus following desumoylation and specifically promotes expression of nuclear-encoded mitochondrial genes (PubMed:29499132). Promotes transcription of nuclear-encoded mitochondrial genes by inhibiting UBE2N/Ubc13 (PubMed:29499132). Can also act as a corepressor as part of the N-Cor repressor complex by repressing active PPARG (PubMed:25519902). Plays an anti-inflammatory role in macrophages and is required for insulin sensitivity by acting as a corepressor (PubMed:27270589). Plays an anti-inflammatory role during the hepatic acute phase response by interacting with sumoylated NR1H2 and NR5A2 proteins, thereby preventing N-Cor corepressor complex dissociation (By similarity). In the cytosol, also plays a non-transcriptional role by regulating insulin signaling and pro-inflammatory pathways (PubMed:22424771, PubMed:28123943). In the cytoplasm, acts as a negative regulator of inflammation by inhibiting the proinflammatory TNF-alpha pathway; acts by repressing UBE2N/Ubc13 activity (PubMed:22424771). In the cytoplasm of adipocytes, restricts the activation of insulin signaling via inhibition of UBE2N/Ubc13-mediated ubiquitination of AKT (PubMed:28123943). Able to suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction (By similarity). {ECO:0000250|UniProtKB:Q13227, ECO:0000269|PubMed:18218630, ECO:0000269|PubMed:22424771, ECO:0000269|PubMed:22666460, ECO:0000269|PubMed:24953653, ECO:0000269|PubMed:25519902, ECO:0000269|PubMed:27270589, ECO:0000269|PubMed:28039360, ECO:0000269|PubMed:28123943, ECO:0000269|PubMed:29499132}.(Source UnitProtKB).

Full Name

G protein pathway suppressor 2

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
3
Biotypes
2
Peaks
82,604
Non-redundant peaks
77,554

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
56310
Official Gene Name
Gps2
JASPAR
MGI
MGI:1891751
Ensembl
ENSMUSG00000023170
UniProt
Q921N8
Genevisible
Q921N8
RefSeq
NM_019726
Aliases
All peaks GPS2
Download BED file
Non redundant peaks GPS2
Download BED file
SEQUENCES GPS2
Download FASTA file
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Datasets Table for GPS2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
GPS2 liver NCOR1-WT GEO Mus musculus GSE113157 70,902
GPS2 3T3-L1 D6 GEO Mus musculus GSE57777 9,118
GPS2 3T3-L1 D0 GEO Mus musculus GSE57777 2,584
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks