HAND2
Information HAND2
- Description
Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. {ECO:0000269|PubMed:10769237, ECO:0000269|PubMed:10804186, ECO:0000269|PubMed:9171826, ECO:0000269|PubMed:9671575}.(Source UnitProtKB).
- Full Name
heart and neural crest derivatives expressed 2
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 4
- Biotypes
- 3
- Peaks
- 36,323
- Non-redundant peaks
- 30,934
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 15111
- Official Gene Name
- Hand2
- JASPAR
- MGI
- MGI:103580
- Ensembl
- ENSMUSG00000038193
- UniProt
- Q61039
- Genevisible
- Q61039
- RefSeq
- Aliases
- AI225906; AI661148; Ehand2; Hed; Th2; Thing2; bHLHa26; dHAND
Datasets Table for HAND2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| HAND2 | mESC | 3FLAG | GEO | Mus musculus | GSE55707 | 11,453 | ||
| HAND2 | heart | GEO | Mus musculus | GSE73368 | 20,810 | |||
| HAND2 | limb-bud | GEO | Mus musculus | GSE55707 | 3,092 | |||
| HAND2 | mESC | GEO | Mus musculus | GSE55707 | 968 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |