HDAC1

Information HDAC1

Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation. {ECO:0000269|PubMed:15226430, ECO:0000269|PubMed:15542849, ECO:0000269|PubMed:17707228, ECO:0000269|PubMed:21960634, ECO:0000269|PubMed:24736997}.(Source UnitProtKB).

Full Name

histone deacetylase 1

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
19
Biotypes
9
Peaks
436,973
Non-redundant peaks
214,158

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
433759
Official Gene Name
Hdac1
JASPAR
MGI
MGI:108086
Ensembl
ENSMUSG00000028800
UniProt
O09106
Genevisible
O09106
RefSeq
NM_008228
Aliases
HD1; MommeD5; RPD3
All peaks HDAC1
Download BED file
Non redundant peaks HDAC1
Download BED file
SEQUENCES HDAC1
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for HDAC1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
HDAC1 pre-iPSC GEO Mus musculus GSE90893 32,858
HDAC1 MEF GEO Mus musculus GSE90893 55,628
HDAC1 MEF GEO Mus musculus GSE72121 208
HDAC1 Th17 GEO Mus musculus GSE92531 14,967
HDAC1 B-cell activated GEO Mus musculus GSE82144 41,907
HDAC1 mESC FS2-vec GEO Mus musculus GSE112113 17,113
HDAC1 mESC GEO Mus musculus GSE55404 165
HDAC1 mESC GEO Mus musculus GSE90893 65,439
HDAC1 mESC GEO Mus musculus GSE66025 2,197
HDAC1 BMDM GEO Mus musculus GSE106701 47,169
HDAC1 BMDM IL4 GEO Mus musculus GSE106701 40,293
HDAC1 myoblast GEO Mus musculus GSE24852 40,737
HDAC1 hemogenic-endothelium lox GEO Mus musculus GSE101681 6,474
HDAC1 hemogenic-endothelium loxlox GEO Mus musculus GSE101681 7,906
HDAC1 B-cell resting GEO Mus musculus GSE82144 19,803
HDAC1 mESC GEO Mus musculus GSE56876 1,410
HDAC1 mESC GEO Mus musculus GSE27841 19,939
HDAC1 mESC GEO Mus musculus GSE112113 17,398
HDAC1 NIH3T3 GEO Mus musculus GSE110382 5,362
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks