HDAC2

Information HDAC2

Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A. {ECO:0000250|UniProtKB:Q92769, ECO:0000269|PubMed:15226430, ECO:0000269|PubMed:17707228, ECO:0000269|PubMed:20071335}.

Full Name

histone deacetylase 2

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
12
Biotypes
8
Peaks
398,237
Non-redundant peaks
222,170

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
15182
Official Gene Name
Hdac2
JASPAR
MGI
MGI:1097691
Ensembl
ENSMUSG00000019777
UniProt
P70288
Genevisible
P70288
RefSeq
NM_008229
Aliases
D10Wsu179e; YAF1; Yy1bp; mRPD3
All peaks HDAC2
Download BED file
Non redundant peaks HDAC2
Download BED file
SEQUENCES HDAC2
Download FASTA file
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Datasets Table for HDAC2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
HDAC2 preadipocyte D0 GEO Mus musculus GSE95533 65,063
HDAC2 B-cell resting GEO Mus musculus GSE82144 42,300
HDAC2 B-cell activated GEO Mus musculus GSE82144 72,198
HDAC2 mESC GEO Mus musculus GSE27841 45,848
HDAC2 heart CKO GEO Mus musculus GSE73769 8,430
HDAC2 BMDM IL4 GEO Mus musculus GSE106701 44,015
HDAC2 BMDM GEO Mus musculus GSE106701 42,516
HDAC2 heart heto GEO Mus musculus GSE73769 9,111
HDAC2 myoblast GEO Mus musculus GSE24852 47,962
HDAC2 hemogenic-endothelium GEO Mus musculus GSE101681 6,674
HDAC2 hemogenic-endothelium lox GEO Mus musculus GSE101681 1,539
HDAC2 NIH3T3 GEO Mus musculus GSE110382 12,581
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks