HDAC6

Information HDAC6

Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:9891014). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:9891014). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:9891014). In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed:19893491). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (By similarity). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (PubMed:22819792). {ECO:0000250|UniProtKB:Q9UBN7, ECO:0000269|PubMed:19893491, ECO:0000269|PubMed:22819792, ECO:0000269|PubMed:9891014}.(Source UnitProtKB).

Full Name

histone deacetylase 6

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
237
Non-redundant peaks
237

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
15185
Official Gene Name
Hdac6
JASPAR
MGI
MGI:1333752
Ensembl
ENSMUSG00000031161
UniProt
Q9Z2V5
Genevisible
Q9Z2V5
RefSeq
Aliases
Hd6; Hdac5; Sfc6; mHDA2
All peaks HDAC6
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Non redundant peaks HDAC6
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SEQUENCES HDAC6
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Datasets Table for HDAC6

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
HDAC6 mESC Kat5-KD GEO Mus musculus GSE42209 237
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks