HDAC7

Information HDAC7

Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Positively regulates the transcriptional repressor activity of FOXP3 (By similarity). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (By similarity). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity). {ECO:0000250|UniProtKB:Q8WUI4, ECO:0000269|PubMed:10640276}.(Source UnitProtKB).

Full Name

histone deacetylase 7

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
1,737
Non-redundant peaks
1,737

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
56233
Official Gene Name
Hdac7
JASPAR
MGI
MGI:1891835
Ensembl
ENSMUSG00000022475
UniProt
Q8C2B3
Genevisible
Q8C2B3
RefSeq
NM_019572
Aliases
5830434K02Rik; Hdac7a
All peaks HDAC7
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Non redundant peaks HDAC7
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SEQUENCES HDAC7
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Datasets Table for HDAC7

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
HDAC7 Th17 GEO Mus musculus GSE92531 1,737
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks