HES1
Information HES1
- Description
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). {ECO:0000250}.(Source UnitProtKB).
- Full Name
hes family bHLH transcription factor 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 2
- Biotypes
- 1
- Peaks
- 12,502
- Non-redundant peaks
- 7,583
TF Classification
- Familly
- Basic helix-loop-helix factors (bHLH)
- Sub Familly
- Hairy-related factors
Source JASPAR
External IDs
- NCBI Gene
- 15205
- Official Gene Name
- Hes1
- JASPAR
- MA1099.1
- MGI
- MGI:104853
- Ensembl
- ENSMUSG00000022528
- UniProt
- P35428
- Genevisible
- P35428
- RefSeq
- NM_008235
- Aliases
- Hry; bHLHb39
Datasets Table for HES1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| HES1 | BMDM | GEO | Mus musculus | GSE77334 | 6,493 | |||
| HES1 | BMDM | LPS-1h | GEO | Mus musculus | GSE77334 | 6,009 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |