HOPX
Information HOPX
- Description
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (PubMed:12297045, PubMed:12297046). Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (By similarity). {ECO:0000250|UniProtKB:Q9BPY8, ECO:0000269|PubMed:12297045, ECO:0000269|PubMed:12297046}.(Source UnitProtKB).
- Full Name
HOP homeobox
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 2
- Biotypes
- 1
- Peaks
- 23,243
- Non-redundant peaks
- 19,449
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 74318
- Official Gene Name
- Hopx
- JASPAR
- MGI
- MGI:1916782
- Ensembl
- ENSMUSG00000059325
- UniProt
- Q8R1H0
- Genevisible
- Q8R1H0
- RefSeq
- NM_175606
- Aliases
- 1110018K11Rik; 1200015P04Rik; 2300002F06Rik; Cameo; Hod; Hop; Ob1; Toto
Datasets Table for HOPX
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| HOPX | TSC | GEO | Mus musculus | GSE110950 | 4,841 | |||
| HOPX | TSC | differentiated | GEO | Mus musculus | GSE110950 | 18,402 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |