IRF1

Information IRF1

Description

Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750, PubMed:20049431). Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750, PubMed:20049431). Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750, PubMed:20049431). Binds to a consensus sequence in gene promoters (By similarity). Its target genes for transcriptional activation activity are: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1 (PubMed:12387893, PubMed:17018642, PubMed:18955028, PubMed:21909274, PubMed:20308629, PubMed:29321274, PubMed:30635240). Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4 (PubMed:18641303). Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53 (By similarity). Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750, PubMed:20049431). Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750, PubMed:20049431). Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750, PubMed:20049431). {ECO:0000250|UniProtKB:P10914, ECO:0000269|PubMed:11244049, ECO:0000269|PubMed:11846971, ECO:0000269|PubMed:11846974, ECO:0000269|PubMed:12387893, ECO:0000269|PubMed:16932750, ECO:0000269|PubMed:17018642, ECO:0000269|PubMed:18641303, ECO:0000269|PubMed:18955028, ECO:0000269|PubMed:20049431, ECO:0000269|PubMed:20308629, ECO:0000269|PubMed:21909274, ECO:0000269|PubMed:29321274, ECO:0000269|PubMed:30635240, ECO:0000303|PubMed:11244049, ECO:0000303|PubMed:11846971, ECO:0000303|PubMed:11846974, ECO:0000303|PubMed:16932750, ECO:0000303|PubMed:20049431}.(Source UnitProtKB).

Full Name

interferon regulatory factor 1

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
19
Biotypes
4
Peaks
169,629
Non-redundant peaks
67,877

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
16362
Official Gene Name
Irf1
JASPAR
MGI
MGI:96590
Ensembl
ENSMUSG00000018899
UniProt
P15314
Genevisible
P15314
RefSeq
NM_008390
Aliases
AU020929; Irf-1
All peaks IRF1
Download BED file
Non redundant peaks IRF1
Download BED file
SEQUENCES IRF1
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for IRF1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
IRF1 AT-3 GEO Mus musculus GSE94130 1,813
IRF1 AT-3 Combo GEO Mus musculus GSE94130 3,564
IRF1 BMDC GEO Mus musculus GSE36099 10,794
IRF1 BMDC 2h GEO Mus musculus GSE36099 34,647
IRF1 BMDC 30min GEO Mus musculus GSE36099 7,960
IRF1 BMDC 1h GEO Mus musculus GSE36099 17,776
IRF1 intestine GEO Mus musculus GSE66069 3,257
IRF1 intestine Prdm1-mut GEO Mus musculus GSE66069 1,133
IRF1 BMDM 1h GEO Mus musculus GSE100962 3,958
IRF1 BMDM GEO Mus musculus GSE77884 2,939
IRF1 BMDM 6h GEO Mus musculus GSE100962 9,733
IRF1 BMDM 0h GEO Mus musculus GSE100962 4,400
IRF1 BMDM IFNg-IL4-4h GEO Mus musculus GSE84518 10,874
IRF1 BMDM IFNg-30min GEO Mus musculus GSE77884 9,996
IRF1 BMDM 2h GEO Mus musculus GSE100962 9,230
IRF1 BMDM IFNg-3h GEO Mus musculus GSE77884 19,275
IRF1 BMDM IFNg-4h GEO Mus musculus GSE84518 12,053
IRF1 AT-3 IFNg GEO Mus musculus GSE94130 4,790
IRF1 AT-3 JQ1 GEO Mus musculus GSE94130 1,437
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks