IRF1

Information IRF1

Description

The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017]

Full Name

interferon regulatory factor 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
19
Biotypes
7
Peaks
168,466
Non-redundant peaks
105,320

TF Classification

Super Class
Helix-turn-helix domains
Class
Tryptophan cluster factors
Familly
Interferon-regulatory factors
Sub Familly
None

Source TFClass

External IDs

NCBI Gene
3659
Official Gene Name
IRF1
JASPAR
MA0050
Ensembl
ENSG00000125347
UniProt
P10914
Genevisible
P10914
RefSeq
NM_001354924
Aliases
IRF-1; MAR

External links
All peaks IRF1
Download BED file
Non redundant peaks IRF1
Download BED file
SEQUENCES IRF1
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for IRF1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
IRF1 CD14 LPS GEO Homo sapiens GSE43036 11,054
IRF1 CD14 GEO Homo sapiens GSE43036 366
IRF1 U-937 GEO Homo sapiens GSE142197 2,352
IRF1 U-937 ZnSO4 GEO Homo sapiens GSE142197 1,264
IRF1 monocyte notreatment GEO Homo sapiens GSE100381 15,741
IRF1 monocyte nopretreatment GEO Homo sapiens GSE100381 5,211
IRF1 PDAC GEO Homo sapiens GSE64557 36,699
IRF1 K-562 EPZ GEO Homo sapiens GSE129380 23,210
IRF1 K-562 GEO Homo sapiens GSE129380 6,200
IRF1 K-562 ENCODE Homo sapiens ENCSR000EGU 683
IRF1 K-562 ENCODE Homo sapiens ENCSR854MCV 16,264
IRF1 K-562 ENCODE Homo sapiens ENCSR000EGK 1,944
IRF1 K-562 ENCODE Homo sapiens ENCSR000EGT 9,748
IRF1 K-562 ENCODE Homo sapiens ENCSR000EGL 3,113
IRF1 AsPC-1 GEO Homo sapiens GSE141606 5,710
IRF1 AsPC-1 IFNg GEO Homo sapiens GSE141606 8,788
IRF1 AsPC-1 ZBED2-cDNA GEO Homo sapiens GSE141606 7,237
IRF1 HAEC IL1b_4h GEO Homo sapiens GSE89970 8,174
IRF1 HAEC TNFa_4h GEO Homo sapiens GSE89970 4,708
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks