IRF3

Information IRF3

Description

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:15800576). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:15800576). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:16846591, PubMed:16979567, PubMed:20049431). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16846591, PubMed:16979567, PubMed:20049431). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591, PubMed:16979567, PubMed:20049431). {ECO:0000269|PubMed:15800576, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}.(Source UnitProtKB).

Full Name

interferon regulatory factor 3

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
6
Biotypes
2
Peaks
206,453
Non-redundant peaks
131,192

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
54131
Official Gene Name
Irf3
JASPAR
MGI
MGI:1859179
Ensembl
ENSMUSG00000003184
UniProt
P70671
Genevisible
P70671
RefSeq
Aliases
C920001K05Rik; IRF-3
All peaks IRF3
Download BED file
Non redundant peaks IRF3
Download BED file
SEQUENCES IRF3
Download FASTA file
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Datasets Table for IRF3

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
IRF3 CD8-pos plC GEO Mus musculus GSE106730 33,089
IRF3 BMDM lipidA-1h GEO Mus musculus GSE67343 8,214
IRF3 BMDM Dex_LPS GEO Mus musculus GSE31796 78,933
IRF3 CD8-pos CpG GEO Mus musculus GSE106730 17,638
IRF3 CD8-pos plC GEO Mus musculus GSE125340 53,670
IRF3 CD8-pos GEO Mus musculus GSE106730 14,909
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks