IRF3
Information IRF3
- Description
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses (PubMed:15800576). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:15800576). Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction (PubMed:16846591, PubMed:16979567, PubMed:20049431). Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases (PubMed:16846591, PubMed:16979567, PubMed:20049431). This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes (PubMed:16846591, PubMed:16979567, PubMed:20049431). Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages (PubMed:16846591, PubMed:16979567, PubMed:20049431). {ECO:0000269|PubMed:15800576, ECO:0000303|PubMed:16846591, ECO:0000303|PubMed:16979567, ECO:0000303|PubMed:20049431}.(Source UnitProtKB).
- Full Name
interferon regulatory factor 3
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 6
- Biotypes
- 2
- Peaks
- 206,453
- Non-redundant peaks
- 131,192
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 54131
- Official Gene Name
- Irf3
- JASPAR
- MGI
- MGI:1859179
- Ensembl
- ENSMUSG00000003184
- UniProt
- P70671
- Genevisible
- P70671
- RefSeq
- Aliases
- C920001K05Rik; IRF-3
Datasets Table for IRF3
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
IRF3 | CD8-pos | plC | GEO | Mus musculus | GSE106730 | 33,089 | ||
IRF3 | BMDM | lipidA-1h | GEO | Mus musculus | GSE67343 | 8,214 | ||
IRF3 | BMDM | Dex_LPS | GEO | Mus musculus | GSE31796 | 78,933 | ||
IRF3 | CD8-pos | CpG | GEO | Mus musculus | GSE106730 | 17,638 | ||
IRF3 | CD8-pos | plC | GEO | Mus musculus | GSE125340 | 53,670 | ||
IRF3 | CD8-pos | GEO | Mus musculus | GSE106730 | 14,909 | |||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |