IRF4

Information IRF4

Description

Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes. {ECO:0000269|PubMed:22983707, ECO:0000269|PubMed:22992523, ECO:0000269|PubMed:22992524}.(Source UnitProtKB).

Full Name

interferon regulatory factor 4

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
47
Biotypes
15
Peaks
1,224,327
Non-redundant peaks
233,294

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
16364
Official Gene Name
Irf4
JASPAR
MGI
MGI:1096873
Ensembl
ENSMUSG00000021356
UniProt
Q64287
Genevisible
Q64287
RefSeq
NM_013674
Aliases
AI385587; IRF-4; LSIRF; NF-EM5; Spip

External links
All peaks IRF4
Download BED file
Non redundant peaks IRF4
Download BED file
SEQUENCES IRF4
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for IRF4

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
IRF4 spleen GEO Mus musculus GSE98263 15,954
IRF4 spleen Rela-KO GEO Mus musculus GSE98263 12,161
IRF4 spleen Bach2-KO GEO Mus musculus GSE126800 11,896
IRF4 pre-B-cell WT GEO Mus musculus GSE86897 22,546
IRF4 BMDC LPS-6h GEO Mus musculus GSE40727 40,202
IRF4 BMDC 30min GEO Mus musculus GSE36099 6,600
IRF4 BMDC 1h GEO Mus musculus GSE36099 138
IRF4 Th17 Batf-WT GEO Mus musculus GSE40918 65,998
IRF4 Th17 Batf-pos-pos GEO Mus musculus GSE40918 75,929
IRF4 Th17 3h GEO Mus musculus GSE40918 44,482
IRF4 Th17 GEO Mus musculus GSE40918 32,980
IRF4 Th17 42h GEO Mus musculus GSE40727 14,053
IRF4 Th17 GEO Mus musculus GSE39756 29,306
IRF4 plasmablast GEO Mus musculus GSE71698 32,092
IRF4 small-pre-B brwd1-KO GEO Mus musculus GSE103057 9,654
IRF4 lymphocyte Treg-KO GEO Mus musculus GSE121294 45,287
IRF4 lymphocyte Treg GEO Mus musculus GSE121294 48,972
IRF4 primary-B-cell d1 GEO Mus musculus GSE46607 878
IRF4 CD8-pos GEO Mus musculus GSE49930 3,073
IRF4 Th2 BATF-KO GEO Mus musculus GSE85172 32,726
IRF4 Th2 DKO GEO Mus musculus GSE85172 3,480
IRF4 Th2 WT GEO Mus musculus GSE85172 34,973
IRF4 Th2 GEO Mus musculus GSE85172 74,368
IRF4 Th2 2ng GEO Mus musculus GSE85172 20,167
IRF4 Th0 42h GEO Mus musculus GSE40727 1,933
IRF4 Th0 Batf-WT GEO Mus musculus GSE40918 44,774
IRF4 Th0 GEO Mus musculus GSE40918 40,998
IRF4 Th0 Batf-pos-pos GEO Mus musculus GSE40918 31,425
IRF4 Th0 Batf-KO GEO Mus musculus GSE40918 32,049
IRF4 Th0 Batf-neg-neg GEO Mus musculus GSE40918 13,578
IRF4 small-pre-B GEO Mus musculus GSE103057 14,584
IRF4 pre-plasmablast GEO Mus musculus GSE71698 29,055
IRF4 primary-B-cell d3 GEO Mus musculus GSE46607 573
IRF4 Th2 42h GEO Mus musculus GSE40727 495
IRF4 Th2 d2 GEO Mus musculus GSE85172 13,919
IRF4 Th2 Batf-HKE-OE GEO Mus musculus GSE85172 7,288
IRF4 Th2 10ng GEO Mus musculus GSE85172 40,810
IRF4 pre-B-cell IKDN GEO Mus musculus GSE86897 36,050
IRF4 spleen GEO Mus musculus GSE126800 18,321
IRF4 Th17 Batf-neg-neg GEO Mus musculus GSE40918 48,026
IRF4 Th17 16h GEO Mus musculus GSE40918 34,503
IRF4 Th17 Batf-KO GEO Mus musculus GSE40918 37,690
IRF4 pro-B-cell GEO Mus musculus GSE53595 30,658
IRF4 CH12-LX ENCODE Mus musculus ENCSR743ZJL 28,973
IRF4 B-cell GEO Mus musculus GSE71698 19,420
IRF4 CD8-pos GEO Mus musculus GSE54191 7,683
IRF4 BMDC GEO Mus musculus GSE36099 13,607
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks