IRF5
Information IRF5
- Description
Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:15665823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:15665823). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (PubMed:15665823). {ECO:0000269|PubMed:15665823}.(Source UnitProtKB).
- Full Name
interferon regulatory factor 5
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 4
- Biotypes
- 1
- Peaks
- 110,026
- Non-redundant peaks
- 56,498
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 27056
- Official Gene Name
- Irf5
- JASPAR
- MGI
- MGI:1350924
- Ensembl
- ENSMUSG00000029771
- UniProt
- P56477
- Genevisible
- P56477
- RefSeq
- NM_012057
- Aliases
- AW491843; mirf5
Datasets Table for IRF5
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| IRF5 | CD8-pos | plC | GEO | Mus musculus | GSE106730 | 28,650 | ||
| IRF5 | CD8-pos | GEO | Mus musculus | GSE106730 | 14,637 | |||
| IRF5 | CD8-pos | CpG | GEO | Mus musculus | GSE125340 | 42,812 | ||
| IRF5 | CD8-pos | CpG | GEO | Mus musculus | GSE106730 | 23,927 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |