IRF8

Information IRF8

Description

The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Full Name

interferon regulatory factor 8

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
27
Biotypes
9
Peaks
496,639
Non-redundant peaks
132,966

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
15900
Official Gene Name
Irf8
JASPAR
MGI
MGI:96395
Ensembl
ENSMUSG00000041515
UniProt
P23611
Genevisible
P23611
RefSeq
Aliases
AI893568; ICSBP; IRF-8; Icsbp1; Myls

External links
All peaks IRF8
Download BED file
Non redundant peaks IRF8
Download BED file
SEQUENCES IRF8
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for IRF8

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
IRF8 spleen GC-B-cell GEO Mus musculus GSE70710 1,918
IRF8 spleen 72h GEO Mus musculus GSE70710 182
IRF8 spleen GEO Mus musculus GSE99165 442
IRF8 dendritic-cell Irf8-KO GEO Mus musculus GSE53311 6,299
IRF8 dendritic-cell CD24 GEO Mus musculus GSE66899 53,569
IRF8 dendritic-cell GEO Mus musculus GSE66899 1,959
IRF8 CD8-pos CpG GEO Mus musculus GSE106730 50,984
IRF8 bone-marrow pDC GEO Mus musculus GSE62702 27,671
IRF8 lymph-node GEO Mus musculus GSE128166 6,376
IRF8 BMDM GEO Mus musculus GSE77884 6,564
IRF8 BMDM IFNg-30min GEO Mus musculus GSE77884 7,774
IRF8 BMDM IFNg-3h GEO Mus musculus GSE77884 9,944
IRF8 BMDM BXH2 GEO Mus musculus GSE56121 5,820
IRF8 BMDM BXH2_LPS-4h GEO Mus musculus GSE56121 9,311
IRF8 BMDM BXH2_LPS-2h GEO Mus musculus GSE56121 11,618
IRF8 BMDM LPS-2h GEO Mus musculus GSE56121 26,279
IRF8 BMDM LPS-4h GEO Mus musculus GSE56121 35,991
IRF8 myeloid-progenitor GEO Mus musculus GSE38824 9,011
IRF8 granulocyte-macrophage-progenitor GEO Mus musculus GSE70237 2,683
IRF8 dendritic-cell Batf3-KO GEO Mus musculus GSE53311 43,864
IRF8 dendritic-cell GEO Mus musculus GSE53311 56,754
IRF8 bone-marrow moDC GEO Mus musculus GSE62702 28,336
IRF8 spleen 48h GEO Mus musculus GSE70710 578
IRF8 BMDM GEO Mus musculus GSE56121 20,513
IRF8 CD8-pos plC GEO Mus musculus GSE106730 52,124
IRF8 CD8-pos GEO Mus musculus GSE106730 58,195
IRF8 stomach IFNg GEO Mus musculus GSE67476 3,692
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks