IRF9
Information IRF9
- Description
Transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. {ECO:0000250|UniProtKB:Q00978}.(Source UnitProtKB).
- Full Name
interferon regulatory factor 9
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 5
- Biotypes
- 3
- Peaks
- 102,777
- Non-redundant peaks
- 72,478
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 16391
- Official Gene Name
- Irf9
- JASPAR
- MGI
- MGI:107587
- Ensembl
- ENSMUSG00000002325
- UniProt
- Q61179
- Genevisible
- Q61179
- RefSeq
- NM_008394
- Aliases
- Irf-9; Isgf3g; p48
Datasets Table for IRF9
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| IRF9 | CD8-pos | IFN-beta | GEO | Mus musculus | GSE125340 | 54,683 | ||
| IRF9 | BMDM | IFNb | GEO | Mus musculus | GSE115433 | 31,687 | ||
| IRF9 | BMDM | IFNg | GEO | Mus musculus | GSE115433 | 12,955 | ||
| IRF9 | MEF | GEO | Mus musculus | GSE128107 | 122 | |||
| IRF9 | MEF | IFNb-90min | GEO | Mus musculus | GSE128107 | 3,330 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |