ISL1-2
Information ISL1-2
- Description
Targets ISL1 and 2. DNA-binding transcriptional activator (PubMed:14664703, PubMed:24643061, PubMed:25775587, PubMed:22343712). Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes (PubMed:24643061, PubMed:25775587). Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation (PubMed:25775587). Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina (PubMed:24643061, PubMed:25775587). Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (PubMed:18583962). Binds to insulin gene enhancer sequences (By similarity). (Source UniProtKB)
- Full Name
ISL1-2
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 5
- Biotypes
- 5
- Peaks
- 192,213
- Non-redundant peaks
- 110,543
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
Datasets Table for ISL1-2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| ISL1-2 | motor-neuron | d4 | GEO | Mus musculus | GSE31456 | 64,703 | ||
| ISL1-2 | mESC | GEO | Mus musculus | GSE31456 | 42,159 | |||
| ISL1-2 | induced-cortical-motor-neuron | GEO | Mus musculus | GSE31456 | 21,596 | |||
| ISL1-2 | neuron | d4_il | GEO | Mus musculus | GSE31456 | 42,159 | ||
| ISL1-2 | cortical-motor-neuron | d4_iNIP | GEO | Mus musculus | GSE31456 | 21,596 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |