JARID2

Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis (PubMed:10807864, PubMed:12852854, PubMed:12890668, PubMed:15542826, PubMed:15870077, PubMed:19010785, PubMed:20064375, PubMed:20064376, PubMed:20075857). Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin (PubMed:20064376, PubMed:20064375). Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development (PubMed:20064375, PubMed:20075857). In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases (PubMed:12852854, PubMed:12890668, PubMed:19010785). Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5 (PubMed:15542826). Participates in the negative regulation of cell proliferation signaling (PubMed:10913339). Does not have histone demethylase activity (PubMed:20064376). {ECO:0000269|PubMed:10807864, ECO:0000269|PubMed:10913339, ECO:0000269|PubMed:12852854, ECO:0000269|PubMed:12890668, ECO:0000269|PubMed:15542826, ECO:0000269|PubMed:15870077, ECO:0000269|PubMed:19010785, ECO:0000269|PubMed:20064375, ECO:0000269|PubMed:20064376, ECO:0000269|PubMed:20075857}.(Source UnitProtKB).

jumonji, AT rich interactive domain 2

Source UniprotKB

Mus musculus [tax_id: 10090]

mm10