KAT2A
Information KAT2A
- Description
Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (PubMed:28424240). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity). Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (By similarity). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (By similarity). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (By similarity). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:28424240). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (By similarity). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (PubMed:25024434). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (PubMed:28424240). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (PubMed:30424580). Regulates embryonic stem cell (ESC) pluripotency and differentiation (PubMed:30270482). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (By similarity). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (By similarity). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (By similarity). {ECO:0000250|UniProtKB:Q92830, ECO:0000269|PubMed:17301242, ECO:0000269|PubMed:25024434, ECO:0000269|PubMed:28424240, ECO:0000269|PubMed:30270482, ECO:0000269|PubMed:30424580}.(Source UnitProtKB).
- Full Name
K(lysine) acetyltransferase 2A
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 4
- Biotypes
- 3
- Peaks
- 33,947
- Non-redundant peaks
- 22,309
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 14534
- Official Gene Name
- Kat2a
- JASPAR
- MGI
- MGI:1343101
- Ensembl
- ENSMUSG00000020918
- UniProt
- Q9JHD2
- Genevisible
- Q9JHD2
- RefSeq
- NM_020004
- Aliases
- 1110051E14Rik; AW212720; Gcn5; Gcn5l2; PCAF-B/GCN5; mmGCN5
Datasets Table for KAT2A
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
KAT2A | MEL | ENCODE | Mus musculus | ENCSR000ESM | 3,256 | |||
KAT2A | CH12-LX | ENCODE | Mus musculus | ENCSR000EQU | 3,290 | |||
KAT2A | B-cell | resting | GEO | Mus musculus | GSE82144 | 19,259 | ||
KAT2A | B-cell | activated | GEO | Mus musculus | GSE82144 | 8,142 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |