KAT2A

Information KAT2A

Description

Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (PubMed:28424240). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity). Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (By similarity). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (By similarity). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (By similarity). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:28424240). Recruited by the XPC complex at promoters, where it specifically mediates acetylation of histone variant H2A.Z.1/H2A.Z, thereby promoting expression of target genes (By similarity). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (PubMed:25024434). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at 'Lys-9' (H3K9ac), leading to promote IL2 expression (PubMed:28424240). Required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) (PubMed:30424580). Regulates embryonic stem cell (ESC) pluripotency and differentiation (PubMed:30270482). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (By similarity). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (By similarity). Also acts as a histone glutaryltransferase: catalyzes glutarylation of histone H4 on 'Lys-91' (H4K91glu), a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes (By similarity). {ECO:0000250|UniProtKB:Q92830, ECO:0000269|PubMed:17301242, ECO:0000269|PubMed:25024434, ECO:0000269|PubMed:28424240, ECO:0000269|PubMed:30270482, ECO:0000269|PubMed:30424580}.(Source UnitProtKB).

Full Name

K(lysine) acetyltransferase 2A

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
4
Biotypes
3
Peaks
33,947
Non-redundant peaks
22,309

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
14534
Official Gene Name
Kat2a
JASPAR
MGI
MGI:1343101
Ensembl
ENSMUSG00000020918
UniProt
Q9JHD2
Genevisible
Q9JHD2
RefSeq
NM_020004
Aliases
1110051E14Rik; AW212720; Gcn5; Gcn5l2; PCAF-B/GCN5; mmGCN5
All peaks KAT2A
Download BED file
Non redundant peaks KAT2A
Download BED file
SEQUENCES KAT2A
Download FASTA file
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Datasets Table for KAT2A

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
KAT2A MEL ENCODE Mus musculus ENCSR000ESM 3,256
KAT2A CH12-LX ENCODE Mus musculus ENCSR000EQU 3,290
KAT2A B-cell resting GEO Mus musculus GSE82144 19,259
KAT2A B-cell activated GEO Mus musculus GSE82144 8,142
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks