KAT2B
Information KAT2B
- Description
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY, PLK4, RRP9/U3-55K and TBX5. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5. Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4. Acetylates RRP9/U3-55K, a core subunit of the U3 snoRNP complex, impairing pre-rRNA processing. Also acetylates spermidine. {ECO:0000250|UniProtKB:Q92831}.(Source UnitProtKB).
- Full Name
K(lysine) acetyltransferase 2B
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 1
- Biotypes
- 1
- Peaks
- 1,343
- Non-redundant peaks
- 1,343
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 18519
- Official Gene Name
- Kat2b
- JASPAR
- MGI
- MGI:1343094
- Ensembl
- ENSMUSG00000000708
- UniProt
- Q9JHD1
- Genevisible
- Q9JHD1
- RefSeq
- NM_020005
- Aliases
- A930006P13Rik; AI461839; AW536563; Pcaf; p/CAF