KDM1A

Information KDM1A

Description

Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation (By similarity). Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7. {ECO:0000250|UniProtKB:O60341, ECO:0000269|PubMed:17707228, ECO:0000269|PubMed:19098913}.(Source UnitProtKB).

Full Name

lysine (K)-specific demethylase 1A

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
26
Biotypes
12
Peaks
523,929
Non-redundant peaks
246,203

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
99982
Official Gene Name
Kdm1a
JASPAR
MGI
MGI:1196256
Ensembl
ENSMUSG00000036940
UniProt
Q6ZQ88
Genevisible
Q6ZQ88
RefSeq
NM_133872
Aliases
1810043O07Rik; Aof2; Kdm1; LSD1
All peaks KDM1A
Download BED file
Non redundant peaks KDM1A
Download BED file
SEQUENCES KDM1A
Download FASTA file
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Datasets Table for KDM1A

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
KDM1A erythroleukemia GEO Mus musculus GSE59859 22,832
KDM1A B16 sc GEO Mus musculus GSE112230 4,132
KDM1A B16 KO GEO Mus musculus GSE112230 263
KDM1A cortical-neuron GEO Mus musculus GSE63271 20,134
KDM1A cortical-neuron KCl_LSD1n_WT GEO Mus musculus GSE63271 20,386
KDM1A C2C12 adipogenic-diff_OE GEO Mus musculus GSE98134 14,966
KDM1A C2C12 myogenic-diff GEO Mus musculus GSE98134 21,047
KDM1A C2C12 adipogenic-diff GEO Mus musculus GSE98134 9,491
KDM1A hematopoietic-progenitor GEO Mus musculus GSE110896 28,253
KDM1A trophoblast-stem-cell GEO Mus musculus GSE78264 17,770
KDM1A mESC GEO Mus musculus GSE18515 6,243
KDM1A mESC WT-LSD1 GEO Mus musculus GSE99022 73,272
KDM1A pro-B-cell GEO Mus musculus GSE79518 18,432
KDM1A EBs STIL-KO GEO Mus musculus GSE47082 9,566
KDM1A 3T3-L1 d7 GEO Mus musculus GSE50934 7,501
KDM1A 3T3-L1 d7_Kdm1a-OE GEO Mus musculus GSE50934 23,171
KDM1A NSC GEO Mus musculus GSE75039 43,051
KDM1A NSC KO GEO Mus musculus GSE75039 44,950
KDM1A bone-marrow GEO Mus musculus GSE40440 41,628
KDM1A hematopoietic-progenitor stLSDi GEO Mus musculus GSE110896 14,711
KDM1A cortical-neuron LSD1n_KO GEO Mus musculus GSE63271 12,564
KDM1A cortical-neuron KCl GEO Mus musculus GSE63271 13,620
KDM1A pro-B-cell IL3 GEO Mus musculus GSE79518 16,124
KDM1A 3T3-L1 d0_Kdm1a-OE GEO Mus musculus GSE50934 13,571
KDM1A C2C12 MB GEO Mus musculus GSE50590 16,603
KDM1A C2C12 MT GEO Mus musculus GSE50590 9,648
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks