KDM1A
Information KDM1A
- Description
Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation (By similarity). Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7. {ECO:0000250|UniProtKB:O60341, ECO:0000269|PubMed:17707228, ECO:0000269|PubMed:19098913}.(Source UnitProtKB).
- Full Name
lysine (K)-specific demethylase 1A
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 26
- Biotypes
- 12
- Peaks
- 523,929
- Non-redundant peaks
- 246,203
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 99982
- Official Gene Name
- Kdm1a
- JASPAR
- MGI
- MGI:1196256
- Ensembl
- ENSMUSG00000036940
- UniProt
- Q6ZQ88
- Genevisible
- Q6ZQ88
- RefSeq
- NM_133872
- Aliases
- 1810043O07Rik; Aof2; Kdm1; LSD1
Datasets Table for KDM1A
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
KDM1A | erythroleukemia | GEO | Mus musculus | GSE59859 | 22,832 | |||
KDM1A | B16 | sc | GEO | Mus musculus | GSE112230 | 4,132 | ||
KDM1A | B16 | KO | GEO | Mus musculus | GSE112230 | 263 | ||
KDM1A | cortical-neuron | GEO | Mus musculus | GSE63271 | 20,134 | |||
KDM1A | cortical-neuron | KCl_LSD1n_WT | GEO | Mus musculus | GSE63271 | 20,386 | ||
KDM1A | C2C12 | adipogenic-diff_OE | GEO | Mus musculus | GSE98134 | 14,966 | ||
KDM1A | C2C12 | myogenic-diff | GEO | Mus musculus | GSE98134 | 21,047 | ||
KDM1A | C2C12 | adipogenic-diff | GEO | Mus musculus | GSE98134 | 9,491 | ||
KDM1A | hematopoietic-progenitor | GEO | Mus musculus | GSE110896 | 28,253 | |||
KDM1A | trophoblast-stem-cell | GEO | Mus musculus | GSE78264 | 17,770 | |||
KDM1A | mESC | GEO | Mus musculus | GSE18515 | 6,243 | |||
KDM1A | mESC | WT-LSD1 | GEO | Mus musculus | GSE99022 | 73,272 | ||
KDM1A | pro-B-cell | GEO | Mus musculus | GSE79518 | 18,432 | |||
KDM1A | EBs | STIL-KO | GEO | Mus musculus | GSE47082 | 9,566 | ||
KDM1A | 3T3-L1 | d7 | GEO | Mus musculus | GSE50934 | 7,501 | ||
KDM1A | 3T3-L1 | d7_Kdm1a-OE | GEO | Mus musculus | GSE50934 | 23,171 | ||
KDM1A | NSC | GEO | Mus musculus | GSE75039 | 43,051 | |||
KDM1A | NSC | KO | GEO | Mus musculus | GSE75039 | 44,950 | ||
KDM1A | bone-marrow | GEO | Mus musculus | GSE40440 | 41,628 | |||
KDM1A | hematopoietic-progenitor | stLSDi | GEO | Mus musculus | GSE110896 | 14,711 | ||
KDM1A | cortical-neuron | LSD1n_KO | GEO | Mus musculus | GSE63271 | 12,564 | ||
KDM1A | cortical-neuron | KCl | GEO | Mus musculus | GSE63271 | 13,620 | ||
KDM1A | pro-B-cell | IL3 | GEO | Mus musculus | GSE79518 | 16,124 | ||
KDM1A | 3T3-L1 | d0_Kdm1a-OE | GEO | Mus musculus | GSE50934 | 13,571 | ||
KDM1A | C2C12 | MB | GEO | Mus musculus | GSE50590 | 16,603 | ||
KDM1A | C2C12 | MT | GEO | Mus musculus | GSE50590 | 9,648 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |