KDM5A
Information KDM5A
- Description
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4' (PubMed:17320161, PubMed:17320163). Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (By similarity). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (PubMed:21960634). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (By similarity). {ECO:0000250|UniProtKB:P29375, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:21960634}.(Source UnitProtKB).
- Full Name
lysine (K)-specific demethylase 5A
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 3
- Biotypes
- 1
- Peaks
- 106,090
- Non-redundant peaks
- 62,653
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 214899
- Official Gene Name
- Kdm5a
- JASPAR
- MGI
- MGI:2136980
- Ensembl
- ENSMUSG00000030180
- UniProt
- Q3UXZ9
- Genevisible
- Q3UXZ9
- RefSeq
- NM_145997
- Aliases
- Jarid1a; RBP2; Rbbp2
Datasets Table for KDM5A
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
KDM5A | 3T3-L1 | d2 | GEO | Mus musculus | GSE84410 | 28,890 | ||
KDM5A | 3T3-L1 | GEO | Mus musculus | GSE84410 | 32,194 | |||
KDM5A | 3T3-L1 | 4h | GEO | Mus musculus | GSE84410 | 45,006 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |