KDM5A

Information KDM5A

Description

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4' (PubMed:17320161, PubMed:17320163). Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (By similarity). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (PubMed:21960634). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (By similarity). {ECO:0000250|UniProtKB:P29375, ECO:0000269|PubMed:17320161, ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:21960634}.(Source UnitProtKB).

Full Name

lysine (K)-specific demethylase 5A

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
3
Biotypes
1
Peaks
106,090
Non-redundant peaks
62,653

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
214899
Official Gene Name
Kdm5a
JASPAR
MGI
MGI:2136980
Ensembl
ENSMUSG00000030180
UniProt
Q3UXZ9
Genevisible
Q3UXZ9
RefSeq
NM_145997
Aliases
Jarid1a; RBP2; Rbbp2
All peaks KDM5A
Download BED file
Non redundant peaks KDM5A
Download BED file
SEQUENCES KDM5A
Download FASTA file
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Datasets Table for KDM5A

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
KDM5A 3T3-L1 d2 GEO Mus musculus GSE84410 28,890
KDM5A 3T3-L1 GEO Mus musculus GSE84410 32,194
KDM5A 3T3-L1 4h GEO Mus musculus GSE84410 45,006
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks