KDM6B
Information KDM6B
- Description
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (PubMed:21095589). {ECO:0000269|PubMed:17825402, ECO:0000269|PubMed:21095589}.(Source UnitProtKB).
- Full Name
KDM1 lysine (K)-specific demethylase 6B
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 4
- Biotypes
- 3
- Peaks
- 88,132
- Non-redundant peaks
- 69,323
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 216850
- Official Gene Name
- Kdm6b
- JASPAR
- MGI
- MGI:2448492
- Ensembl
- ENSMUSG00000018476
- UniProt
- Q5NCY0
- Genevisible
- Q5NCY0
- RefSeq
- NM_001017426
- Aliases
- Jmjd3
Datasets Table for KDM6B
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| KDM6B | Th17 | GEO | Mus musculus | GSE40918 | 10,317 | |||
| KDM6B | NSC | GEO | Mus musculus | GSE36673 | 25,917 | |||
| KDM6B | NSC | GEO | Mus musculus | GSE38269 | 51,539 | |||
| KDM6B | 32D | bone-marrow | GEO | Mus musculus | GSE100487 | 359 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |