KDM6B

Information KDM6B

Description

The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]

Full Name

lysine demethylase 6B

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
37,615
Non-redundant peaks
37,615

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
23135
Official Gene Name
KDM6B
JASPAR
Ensembl
ENSG00000132510
UniProt
O15054
Genevisible
O15054
RefSeq
NM_001080424
Aliases
JMJD3; KIAA0346
All peaks KDM6B
Download BED file
Non redundant peaks KDM6B
Download BED file
SEQUENCES KDM6B
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for KDM6B

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
KDM6B CUTLL1 GEO Homo sapiens GSE56694 37,615
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks