KLF1
Information KLF1
- Description
Transcription regulator of erythrocyte development. Binds to the CACCC box in the beta-globin gene promoter and activates transcription. Probably serves as a general switch factor for erythroid development. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation. {ECO:0000269|PubMed:11259590, ECO:0000269|PubMed:15542849, ECO:0000269|PubMed:17938210, ECO:0000269|PubMed:9722526}.
- Full Name
Kruppel-like factor 1 (erythroid)
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 3
- Biotypes
- 2
- Peaks
- 19,103
- Non-redundant peaks
- 16,885
TF Classification
- Familly
- C2H2 zinc finger factors
- Sub Familly
- Three-zinc finger Kruppel-related factors
Source JASPAR
External IDs
- NCBI Gene
- 16596
- Official Gene Name
- Klf1
- JASPAR
- MA0493.1
- MGI
- MGI:1342771
- Ensembl
- ENSMUSG00000054191
- UniProt
- P46099
- Genevisible
- P46099
- RefSeq
- Aliases
- Eklf; Nan
Datasets Table for KLF1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| KLF1 | liver | erythroblast | GEO | Mus musculus | GSE48020 | 13,761 | ||
| KLF1 | liver | erythroid-progenitor | GEO | Mus musculus | GSE48020 | 1,918 | ||
| KLF1 | erythroblast | KLF1_null | GEO | Mus musculus | GSE92620 | 3,424 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |