KLF4

Information KLF4

Description

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:10431239, ECO:0000269|PubMed:10556311, ECO:0000269|PubMed:15358627, ECO:0000269|PubMed:16954384, ECO:0000269|PubMed:17060454, ECO:0000269|PubMed:19816951, ECO:0000269|PubMed:20071344}.(Source UnitProtKB).

Full Name

Kruppel-like factor 4 (gut)

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
44
Biotypes
10
Peaks
1,176,320
Non-redundant peaks
279,141

TF Classification

Familly
C2H2 zinc finger factors
Sub Familly
Three-zinc finger Kruppel-related factors

Source JASPAR

External IDs

NCBI Gene
16600
Official Gene Name
Klf4
JASPAR
MA0039.2
MGI
MGI:1342287
Ensembl
ENSMUSG00000003032
UniProt
Q60793
Genevisible
Q60793
RefSeq
NM_010637
Aliases
EZF; Gklf; Zie

External links
All peaks KLF4
Download BED file
Non redundant peaks KLF4
Download BED file
SEQUENCES KLF4
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for KLF4

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
KLF4 pre-iPSC GEO Mus musculus GSE90893 79,518
KLF4 MEF endo GEO Mus musculus GSE90893 32,844
KLF4 MEF GEO Mus musculus GSE102517 4,201
KLF4 MEF shUbc9 GEO Mus musculus GSE99009 40,516
KLF4 MEF d5 GEO Mus musculus GSE102517 17,914
KLF4 MEF d2 GEO Mus musculus GSE102517 6,931
KLF4 MEF d7 GEO Mus musculus GSE102517 8,218
KLF4 MEF d6 GEO Mus musculus GSE102517 28,562
KLF4 MEF d4 GEO Mus musculus GSE102517 14,598
KLF4 MEF d8 GEO Mus musculus GSE102517 28,790
KLF4 MEF d3 GEO Mus musculus GSE102517 5,858
KLF4 MEF KpMx GEO Mus musculus GSE90893 51,612
KLF4 MEF shCTRL GEO Mus musculus GSE99009 40,776
KLF4 SCC 20Mcells_HighCa GEO Mus musculus GSE104142 15,637
KLF4 SCC 20Mcells_LowCa GEO Mus musculus GSE104142 10,763
KLF4 iPSC GEO Mus musculus GSE129494 18,734
KLF4 B-cell OSKM-2d GEO Mus musculus GSE71215 8,261
KLF4 B-cell OSKM-1d GEO Mus musculus GSE71215 6,864
KLF4 mESC GEO Mus musculus GSE129673 3,195
KLF4 mESC GEO Mus musculus GSE102517 8,677
KLF4 mESC 2I GEO Mus musculus GSE113429 22,168
KLF4 mESC mitotic GEO Mus musculus GSE92846 14,449
KLF4 mESC serum GEO Mus musculus GSE92407 22,263
KLF4 mESC mut GEO Mus musculus GSE129673 3,115
KLF4 mESC d3 GEO Mus musculus GSE113429 30,361
KLF4 mESC d6 GEO Mus musculus GSE113429 29,022
KLF4 mESC d9 GEO Mus musculus GSE113429 29,392
KLF4 NmuMG GEO Mus musculus GSE49445 26,163
KLF4 CGR8 OE GEO Mus musculus GSE49848 42,523
KLF4 bone-marrow GEO Mus musculus GSE76473 11,787
KLF4 MEF KtetO GEO Mus musculus GSE90893 65,790
KLF4 MEF 48h GEO Mus musculus GSE90893 59,034
KLF4 MEF SKpMX GEO Mus musculus GSE90893 51,002
KLF4 MEF OSKpMX GEO Mus musculus GSE90893 54,054
KLF4 MEF OSpMX GEO Mus musculus GSE90893 61,479
KLF4 B-cell GEO Mus musculus GSE71215 810
KLF4 SCC Low GEO Mus musculus GSE104142 5,980
KLF4 mESC GEO Mus musculus GSE90893 34,232
KLF4 mESC 2i-D3 GEO Mus musculus GSE92407 50,833
KLF4 mESC GEO Mus musculus GSE113429 22,871
KLF4 mESC asynchronous GEO Mus musculus GSE92846 27,264
KLF4 mESC GEO Mus musculus GSE49848 57,017
KLF4 CGR8 GEO Mus musculus GSE49848 21,936
KLF4 atherosclerosis KO GEO Mus musculus GSE65812 306
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks