KLF4

Information KLF4

Description

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:10431239, ECO:0000269|PubMed:10556311, ECO:0000269|PubMed:15358627, ECO:0000269|PubMed:16954384, ECO:0000269|PubMed:17060454, ECO:0000269|PubMed:19816951, ECO:0000269|PubMed:20071344}.(Source UnitProtKB).

Full Name

Kruppel-like factor 4 (gut)

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
44
Biotypes
10
Peaks
1,176,320
Non-redundant peaks
279,141

TF Classification

Familly
C2H2 zinc finger factors
Sub Familly
Three-zinc finger Kruppel-related factors

Source JASPAR

External IDs

NCBI Gene
16600
Official Gene Name
Klf4
JASPAR
MA0039.2
MGI
MGI:1342287
Ensembl
ENSMUSG00000003032
UniProt
Q60793
Genevisible
Q60793
RefSeq
NM_010637
Aliases
EZF; Gklf; Zie
All peaks KLF4
Download BED file
Non redundant peaks KLF4
Download BED file
SEQUENCES KLF4
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for KLF4

Target nameTarget modificationEcotype/StrainBiotypeBiotype modificationSourceSpeciesExperimentPeaks
KLF4 pre-iPSC GEO Mus musculus GSE90893 79,518
KLF4 MEF endo GEO Mus musculus GSE90893 32,844
KLF4 MEF GEO Mus musculus GSE102517 4,201
KLF4 MEF shUbc9 GEO Mus musculus GSE99009 40,516
KLF4 MEF d5 GEO Mus musculus GSE102517 17,914
KLF4 MEF d2 GEO Mus musculus GSE102517 6,931
KLF4 MEF d7 GEO Mus musculus GSE102517 8,218
KLF4 MEF d6 GEO Mus musculus GSE102517 28,562
KLF4 MEF d4 GEO Mus musculus GSE102517 14,598
KLF4 MEF d8 GEO Mus musculus GSE102517 28,790
Target nameTarget modificationEcotype/StrainBiotypeBiotype modificationSourceSpeciesExperimentPeaks
Showing 1 to 10 of 44 entries