KMT2A

Information KMT2A

Description

Histone methyltransferase that plays an essential role in early development and hematopoiesis (By similarity). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (By similarity). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation (By similarity). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (By similarity). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (By similarity). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (By similarity). Required for transcriptional activation of HOXA9 (By similarity). Promotes PPP1R15A-induced apoptosis (By similarity). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer (PubMed:21113167). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (PubMed:21113167). Also has auto-methylation activity on Cys-3879 in absence of histone H3 substrate (By similarity). {ECO:0000250|UniProtKB:Q03164, ECO:0000269|PubMed:21113167}.(Source UnitProtKB).

Full Name

lysine (K)-specific methyltransferase 2A

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
5
Biotypes
3
Peaks
82,022
Non-redundant peaks
59,653

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
214162
Official Gene Name
Kmt2a
JASPAR
MGI
MGI:96995
Ensembl
ENSMUSG00000002028
UniProt
P55200
Genevisible
P55200
RefSeq
Aliases
ALL-1; All1; Cxxc7; HTRX1; Mll; Mll1; trithorax Drosophila
All peaks KMT2A
Download BED file
Non redundant peaks KMT2A
Download BED file
SEQUENCES KMT2A
Download FASTA file
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Datasets Table for KMT2A

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
KMT2A C2C12 MB GEO Mus musculus GSE50590 4,120
KMT2A B-cell activated GEO Mus musculus GSE82144 46,671
KMT2A B-cell resting GEO Mus musculus GSE82144 30,424
KMT2A MLL-AF9 MM-401 GEO Mus musculus GSE68821 500
KMT2A MLL-AF9 GEO Mus musculus GSE34261 307
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks