KMT2B
Information KMT2B
- Description
Histone methyltransferase that methylates 'Lys-4' of histone H3 (By similarity). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (By similarity). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (PubMed:20808952). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (PubMed:20808952). {ECO:0000250|UniProtKB:Q9UMN6, ECO:0000269|PubMed:20808952}.(Source UnitProtKB).
- Full Name
lysine (K)-specific methyltransferase 2B
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 7
- Biotypes
- 1
- Peaks
- 219,902
- Non-redundant peaks
- 107,522
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 75410
- Official Gene Name
- Kmt2b
- JASPAR
- MGI
- MGI:109565
- Ensembl
- ENSMUSG00000006307
- UniProt
- O08550
- Genevisible
- O08550
- RefSeq
- NM_029274
- Aliases
- 2610014H22Rik; Mll2; Wbp7
Datasets Table for KMT2B
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| KMT2B | mESC | WT | GEO | Mus musculus | GSE99530 | 9,535 | ||
| KMT2B | mESC | RA | GEO | Mus musculus | GSE98140 | 159,488 | ||
| KMT2B | mESC | double-crosslink | GEO | Mus musculus | GSE52071 | 11,911 | ||
| KMT2B | mESC | LIF | GEO | Mus musculus | GSE52071 | 68,320 | ||
| KMT2B | mESC | 2i | GEO | Mus musculus | GSE52071 | 12,920 | ||
| KMT2B | mESC | GEO | Mus musculus | GSE52071 | 22,254 | |||
| KMT2B | mESC | WT | GEO | Mus musculus | GSE98140 | 43,396 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |