LEF1

Information LEF1

Description

Transcription factor that binds DNA in a sequence-specific manner (By similarity). Participates in the Wnt signaling pathway (PubMed:11445543). Activates transcription of target genes in the presence of CTNNB1 and EP300 (PubMed:12446687). PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (PubMed:11731474). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (By similarity). Regulates T-cell receptor alpha enhancer function (By similarity). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (PubMed:23562159). May play a role in hair cell differentiation and follicle morphogenesis (PubMed:11445543). {ECO:0000250|UniProtKB:Q9UJU2, ECO:0000269|PubMed:11445543, ECO:0000269|PubMed:11731474, ECO:0000269|PubMed:12446687, ECO:0000269|PubMed:23562159}.(Source UnitProtKB).

Full Name

lymphoid enhancer binding factor 1

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
7,206
Non-redundant peaks
7,206

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
16842
Official Gene Name
Lef1
JASPAR
MGI
MGI:96770
Ensembl
ENSMUSG00000027985
UniProt
P27782
Genevisible
P27782
RefSeq
NM_010703
Aliases
3000002B05; AI451430; Lef-1; lymphoid enhancer factor 1
All peaks LEF1
Download BED file
Non redundant peaks LEF1
Download BED file
SEQUENCES LEF1
Download FASTA file
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Datasets Table for LEF1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
LEF1 back-skin GEO Mus musculus GSE100872 7,206
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks