LEF1
Information LEF1
- Description
Transcription factor that binds DNA in a sequence-specific manner (By similarity). Participates in the Wnt signaling pathway (PubMed:11445543). Activates transcription of target genes in the presence of CTNNB1 and EP300 (PubMed:12446687). PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (PubMed:11731474). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (By similarity). Regulates T-cell receptor alpha enhancer function (By similarity). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (PubMed:23562159). May play a role in hair cell differentiation and follicle morphogenesis (PubMed:11445543). {ECO:0000250|UniProtKB:Q9UJU2, ECO:0000269|PubMed:11445543, ECO:0000269|PubMed:11731474, ECO:0000269|PubMed:12446687, ECO:0000269|PubMed:23562159}.(Source UnitProtKB).
- Full Name
lymphoid enhancer binding factor 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 1
- Biotypes
- 1
- Peaks
- 7,206
- Non-redundant peaks
- 7,206
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR