LEF1

Information LEF1

Description

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Full Name

lymphoid enhancer binding factor 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
5
Biotypes
3
Peaks
23,608
Non-redundant peaks
22,356

TF Classification

Super Class
Other all-alpha-helical DNA-binding domains
Class
High-mobility group (HMG) domain factors
Familly
TCF-7-related factors
Sub Familly
None

Source TFClass

External IDs

NCBI Gene
51176
Official Gene Name
LEF1
JASPAR
MA0768
Ensembl
ENSG00000138795
UniProt
Q9UJU2
Genevisible
Q9UJU2
RefSeq
NM_001130713
Aliases
TCF10; TCF1ALPHA; TCF7L3
All peaks LEF1
Download BED file
Non redundant peaks LEF1
Download BED file
SEQUENCES LEF1
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for LEF1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
LEF1 K-562 ENCODE Homo sapiens ENCSR343ELW 20,858
LEF1 K-562 ENCODE Homo sapiens ENCSR832OGB 1,010
LEF1 HEK293T ENCODE Homo sapiens ENCSR240XWM 288
LEF1 hESC GEO Homo sapiens GSE64758 442
LEF1 hESC WNT3A GEO Homo sapiens GSE64758 1,010
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks