LEO1

Information LEO1

Description

Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling (By similarity). {ECO:0000250, ECO:0000269|PubMed:19345177}.(Source UnitProtKB).

Full Name

Leo1, Paf1/RNA polymerase II complex component

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
3
Biotypes
2
Peaks
96,832
Non-redundant peaks
88,302

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
235497
Official Gene Name
Leo1
JASPAR
MGI
MGI:2685031
Ensembl
ENSMUSG00000042487
UniProt
Q5XJE5
Genevisible
Q5XJE5
RefSeq
NM_001039522
Aliases
LOC235497
All peaks LEO1
Download BED file
Non redundant peaks LEO1
Download BED file
SEQUENCES LEO1
Download FASTA file
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Datasets Table for LEO1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
LEO1 C2C12 myoblast GEO Mus musculus GSE72574 46,303
LEO1 C2C12 myotube GEO Mus musculus GSE72574 48,650
LEO1 myotube GEO Mus musculus GSE86249 1,879
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks