LEO1
Information LEO1
- Description
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling (By similarity). {ECO:0000250, ECO:0000269|PubMed:19345177}.(Source UnitProtKB).
- Full Name
Leo1, Paf1/RNA polymerase II complex component
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 3
- Biotypes
- 2
- Peaks
- 96,832
- Non-redundant peaks
- 88,302
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 235497
- Official Gene Name
- Leo1
- JASPAR
- MGI
- MGI:2685031
- Ensembl
- ENSMUSG00000042487
- UniProt
- Q5XJE5
- Genevisible
- Q5XJE5
- RefSeq
- NM_001039522
- Aliases
- LOC235497
Datasets Table for LEO1
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
LEO1 | C2C12 | myoblast | GEO | Mus musculus | GSE72574 | 46,303 | ||
LEO1 | C2C12 | myotube | GEO | Mus musculus | GSE72574 | 48,650 | ||
LEO1 | myotube | GEO | Mus musculus | GSE86249 | 1,879 | |||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |