MAFB
Information MAFB
- Description
Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (PubMed:11823429). {ECO:0000250|UniProtKB:Q9Y5Q3, ECO:0000269|PubMed:10790365, ECO:0000269|PubMed:11823429, ECO:0000269|PubMed:16443760, ECO:0000269|PubMed:16847325, ECO:0000269|PubMed:17548468, ECO:0000269|PubMed:17901057, ECO:0000269|PubMed:18199433, ECO:0000269|PubMed:19143053, ECO:0000269|PubMed:19440205}.(Source UnitProtKB).
- Full Name
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 1
- Biotypes
- 1
- Peaks
- 45,361
- Non-redundant peaks
- 45,361
TF Classification
- Familly
- Basic leucine zipper factors (bZIP)
- Sub Familly
- Maf-related factors
Source JASPAR
External IDs
- NCBI Gene
- 16658
- Official Gene Name
- Mafb
- JASPAR
- MA0117.2
- MGI
- MGI:104555
- Ensembl
- ENSMUSG00000074622
- UniProt
- P54841
- Genevisible
- P54841
- RefSeq
- NM_010658
- Aliases
- Kreisler; Krml; Krml1; kr