MAFB

Information MAFB

Description

Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (PubMed:11823429). {ECO:0000250|UniProtKB:Q9Y5Q3, ECO:0000269|PubMed:10790365, ECO:0000269|PubMed:11823429, ECO:0000269|PubMed:16443760, ECO:0000269|PubMed:16847325, ECO:0000269|PubMed:17548468, ECO:0000269|PubMed:17901057, ECO:0000269|PubMed:18199433, ECO:0000269|PubMed:19143053, ECO:0000269|PubMed:19440205}.(Source UnitProtKB).

Full Name

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
45,361
Non-redundant peaks
45,361

TF Classification

Familly
Basic leucine zipper factors (bZIP)
Sub Familly
Maf-related factors

Source JASPAR

External IDs

NCBI Gene
16658
Official Gene Name
Mafb
JASPAR
MA0117.2
MGI
MGI:104555
Ensembl
ENSMUSG00000074622
UniProt
P54841
Genevisible
P54841
RefSeq
NM_010658
Aliases
Kreisler; Krml; Krml1; kr
All peaks MAFB
Download BED file
Non redundant peaks MAFB
Download BED file
SEQUENCES MAFB
Download FASTA file
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Datasets Table for MAFB

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
MAFB BMDM GEO Mus musculus GSE75722 45,361
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks