MBD1
Information MBD1
- Description
Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:15060159, ECO:0000269|PubMed:9774669}.
- Full Name
methyl-CpG binding domain protein 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 8
- Biotypes
- 2
- Peaks
- 140,177
- Non-redundant peaks
- 108,336
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 17190
- Official Gene Name
- Mbd1
- JASPAR
- MGI
- MGI:1333811
- Ensembl
- ENSMUSG00000024561
- UniProt
- Q9Z2E2
- Genevisible
- Q9Z2E2
- RefSeq
- NM_013594
- Aliases
- Cxxc3; PCM1
Datasets Table for MBD1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| MBD1 | mESC | Mbd1t | GEO | Mus musculus | GSE39610 | 38,884 | ||
| MBD1 | mESC | Mbd1a | GEO | Mus musculus | GSE39610 | 3,597 | ||
| MBD1 | mESC | Mbd1b | GEO | Mus musculus | GSE39610 | 53,529 | ||
| MBD1 | mESC | delTRD | GEO | Mus musculus | GSE39610 | 32,708 | ||
| MBD1 | mESC | delMBD | GEO | Mus musculus | GSE39610 | 10,373 | ||
| MBD1 | mESC | R22C | GEO | Mus musculus | GSE39610 | 201 | ||
| MBD1 | mESC | delMBD_Mbd1b | GEO | Mus musculus | GSE39610 | 222 | ||
| MBD1 | 3T3-L1 | D0 | GEO | Mus musculus | GSE73432 | 663 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |