MBD1

Information MBD1

Description

The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]

Full Name

methyl-CpG binding domain protein 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
2
Biotypes
1
Peaks
35,550
Non-redundant peaks
26,238

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
4152
Official Gene Name
MBD1
JASPAR
Ensembl
ENSG00000141644
UniProt
Q9UIS9
Genevisible
Q9UIS9
RefSeq
NM_001204136
Aliases
CXXC3; PCM1; RFT
All peaks MBD1
Download BED file
Non redundant peaks MBD1
Download BED file
SEQUENCES MBD1
Download FASTA file
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Datasets Table for MBD1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
MBD1 ISOF1 Hep-G2 ENCODE Homo sapiens ENCSR396QWK 14,643
MBD1 Hep-G2 ENCODE Homo sapiens ENCSR260UJI 20,907
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks