MBD1
Information MBD1
- Description
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]
- Full Name
methyl-CpG binding domain protein 1
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 2
- Biotypes
- 1
- Peaks
- 35,550
- Non-redundant peaks
- 26,238
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
External IDs
- NCBI Gene
- 4152
- Official Gene Name
- MBD1
- JASPAR
- Ensembl
- ENSG00000141644
- UniProt
- Q9UIS9
- Genevisible
- Q9UIS9
- RefSeq
- NM_001204136
- Aliases
- CXXC3; PCM1; RFT
Datasets Table for MBD1
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
MBD1 | ISOF1 | Hep-G2 | ENCODE | Homo sapiens | ENCSR396QWK | 14,643 | ||
MBD1 | Hep-G2 | ENCODE | Homo sapiens | ENCSR260UJI | 20,907 | |||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |