MBD2
Information MBD2
- Description
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (By similarity). May enhance the activation of some unmethylated cAMP-responsive promoters (By similarity). Selectively represses transcription activity of methylated rRNA promoters. {ECO:0000250|UniProtKB:Q9UBB5, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9774669}.(Source UnitProtKB).
- Full Name
methyl-CpG binding domain protein 2
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 8
- Biotypes
- 1
- Peaks
- 99,856
- Non-redundant peaks
- 92,720
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 17191
- Official Gene Name
- Mbd2
- JASPAR
- MGI
- MGI:1333813
- Ensembl
- ENSMUSG00000024513
- UniProt
- Q9Z2E1
- Genevisible
- Q9Z2E1
- RefSeq
- NM_010773
- Aliases
- MBD2a
Datasets Table for MBD2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| MBD2 | mESC | EGFP-KD | GEO | Mus musculus | GSE79770 | 68,864 | ||
| MBD2 | mESC | CMV | GEO | Mus musculus | GSE39610 | 688 | ||
| MBD2 | mESC | triple-KO | GEO | Mus musculus | GSE39610 | 300 | ||
| MBD2 | mESC | EGFP-KD | GEO | Mus musculus | GSE86965 | 295 | ||
| MBD2 | mESC | GEO | Mus musculus | GSE79770 | 371 | |||
| MBD2 | mESC | Mbd3-KD | GEO | Mus musculus | GSE86965 | 281 | ||
| MBD2 | mESC | R181C | GEO | Mus musculus | GSE39610 | 465 | ||
| MBD2 | mESC | Mbd2a | GEO | Mus musculus | GSE39610 | 28,592 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |