MBD3
Information MBD3
- Description
This gene encodes a member of the MBD family of nuclear proteins that contain a methyl-CpG binding domain (MBD). The encoded protein is a component of the nucleosome remodeling and histone deacetylation (NuRD) complex. Deletion of this gene causes embryonic lethality in mice. Embryonic stem cells lacking the encoded protein are severely compromised in their ability to differentiate and fail to commit to developmental lineages in the absence of leukemia inhibitory factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
- Full Name
methyl-CpG binding domain protein 3
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 14
- Biotypes
- 3
- Peaks
- 127,820
- Non-redundant peaks
- 71,642
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 17192
- Official Gene Name
- Mbd3
- JASPAR
- MGI
- MGI:1333812
- Ensembl
- ENSMUSG00000035478
- UniProt
- Q9Z2D8
- Genevisible
- Q9Z2D8
- RefSeq
- NM_013595
- Aliases
- AI181826; AU019209
Datasets Table for MBD3
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| MBD3 | NPC | GEO | Mus musculus | GSE117287 | 6,749 | |||
| MBD3 | NPC | GEO | Mus musculus | GSE39610 | 205 | |||
| MBD3 | MEF | iPSC | GEO | Mus musculus | GSE49766 | 4,409 | ||
| MBD3 | mESC | ZFP296-KO_C7 | GEO | Mus musculus | GSE117287 | 4,093 | ||
| MBD3 | mESC | ZFP296-KO_C27 | GEO | Mus musculus | GSE117287 | 16,258 | ||
| MBD3 | mESC | GEO | Mus musculus | GSE80280 | 45,016 | |||
| MBD3 | mESC | GEO | Mus musculus | GSE79770 | 270 | |||
| MBD3 | mESC | triple-KO | GEO | Mus musculus | GSE39610 | 2,474 | ||
| MBD3 | mESC | Mbd3a | GEO | Mus musculus | GSE39610 | 277 | ||
| MBD3 | mESC | GEO | Mus musculus | GSE51522 | 1,257 | |||
| MBD3 | mESC | spikein | GEO | Mus musculus | GSE117287 | 3,704 | ||
| MBD3 | mESC | EGFP-KD | GEO | Mus musculus | GSE79770 | 13,446 | ||
| MBD3 | mESC | GEO | Mus musculus | GSE61188 | 18,521 | |||
| MBD3 | mESC | GEO | Mus musculus | GSE117287 | 11,141 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |