MCM7
Information MCM7
- Description
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
- Full Name
minichromosome maintenance complex component 7
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 3
- Biotypes
- 1
- Peaks
- 1,603
- Non-redundant peaks
- 1,510
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
External IDs
- NCBI Gene
- 4176
- Official Gene Name
- MCM7
- JASPAR
- Ensembl
- ENSG00000166508
- UniProt
- P33993
- Genevisible
- P33993
- RefSeq
- NM_001278595
- Aliases
- CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM; PNAS146; PPP1R104
Datasets Table for MCM7
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| MCM7 | K-562 | ENCODE | Homo sapiens | ENCSR038RGL | 1,140 | |||
| MCM7 | K-562 | ENCODE | Homo sapiens | ENCSR068VRA | 197 | |||
| MCM7 | K-562 | ENCODE | Homo sapiens | ENCSR542WJU | 266 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |