MECP2
Information MECP2
- Description
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000269|PubMed:23434322}.(Source UnitProtKB).
- Full Name
methyl CpG binding protein 2
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 12
- Biotypes
- 6
- Peaks
- 191,795
- Non-redundant peaks
- 145,073
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
Datasets Table for MECP2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| MECP2 | blood | granulocyte | GEO | Mus musculus | GSE85517 | 79,773 | ||
| MECP2 | cortex | Pv-Cre | GEO | Mus musculus | GSE104578 | 8,969 | ||
| MECP2 | cortex | GEO | Mus musculus | GSE104578 | 112 | |||
| MECP2 | brain | G273X | GEO | Mus musculus | GSE36536 | 4,677 | ||
| MECP2 | brain | GEO | Mus musculus | GSE19786 | 15,384 | |||
| MECP2 | mESC | triple-KO | GEO | Mus musculus | GSE39610 | 510 | ||
| MECP2 | mESC | GEO | Mus musculus | GSE39610 | 6,888 | |||
| MECP2 | frontal-cortex | GEO | Mus musculus | GSE107519 | 4,528 | |||
| MECP2 | neuron | post-mitotic | GEO | Mus musculus | GSE39610 | 2,925 | ||
| MECP2 | blood | promyelocyte | GEO | Mus musculus | GSE85517 | 59,974 | ||
| MECP2 | brain | R270X | GEO | Mus musculus | GSE36536 | 5,056 | ||
| MECP2 | mESC | delTRD | GEO | Mus musculus | GSE39610 | 2,999 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |