MED12
Information MED12
- Description
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]
- Full Name
mediator complex subunit 12
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 15
- Biotypes
- 3
- Peaks
- 256,472
- Non-redundant peaks
- 134,452
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
Datasets Table for MED12
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
MED12 | MCF-7 | CARM1_E2 | GEO | Homo sapiens | GSE124448 | 1,362 | ||
MED12 | MCF-7 | CTL | GEO | Homo sapiens | GSE124448 | 158 | ||
MED12 | MCF-7 | CARM1 | GEO | Homo sapiens | GSE124448 | 135 | ||
MED12 | MCF-7 | E2 | GEO | Homo sapiens | GSE124448 | 1,629 | ||
MED12 | MCF-7 | siCTL_E2 | GEO | Homo sapiens | GSE101559 | 1,471 | ||
MED12 | leiomyoma | PT967 | GEO | Homo sapiens | GSE128230 | 21,931 | ||
MED12 | leiomyoma | PT886 | GEO | Homo sapiens | GSE128230 | 60,179 | ||
MED12 | leiomyoma | PT848 | GEO | Homo sapiens | GSE128230 | 16,176 | ||
MED12 | leiomyoma | PT916 | GEO | Homo sapiens | GSE128230 | 8,264 | ||
MED12 | leiomyoma | PT1063 | GEO | Homo sapiens | GSE128230 | 12,011 | ||
MED12 | myometrium | PT1063 | GEO | Homo sapiens | GSE128230 | 19,387 | ||
MED12 | myometrium | PT916 | GEO | Homo sapiens | GSE128230 | 51,878 | ||
MED12 | myometrium | PT967 | GEO | Homo sapiens | GSE128230 | 19,159 | ||
MED12 | myometrium | PT886 | GEO | Homo sapiens | GSE128230 | 37,952 | ||
MED12 | myometrium | PT848 | GEO | Homo sapiens | GSE128230 | 4,780 | ||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |