MED12

Information MED12

Description

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]

Full Name

mediator complex subunit 12

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
15
Biotypes
3
Peaks
256,472
Non-redundant peaks
134,452

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
9968
Official Gene Name
MED12
JASPAR
Ensembl
ENSG00000184634
UniProt
Q93074
Genevisible
Q93074
RefSeq
NM_005120
Aliases
ARC240; CAGH45; FGS1; HOPA; KIAA0192; MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230
All peaks MED12
Download BED file
Non redundant peaks MED12
Download BED file
SEQUENCES MED12
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for MED12

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
MED12 MCF-7 CARM1_E2 GEO Homo sapiens GSE124448 1,362
MED12 MCF-7 CTL GEO Homo sapiens GSE124448 158
MED12 MCF-7 CARM1 GEO Homo sapiens GSE124448 135
MED12 MCF-7 E2 GEO Homo sapiens GSE124448 1,629
MED12 MCF-7 siCTL_E2 GEO Homo sapiens GSE101559 1,471
MED12 leiomyoma PT967 GEO Homo sapiens GSE128230 21,931
MED12 leiomyoma PT886 GEO Homo sapiens GSE128230 60,179
MED12 leiomyoma PT848 GEO Homo sapiens GSE128230 16,176
MED12 leiomyoma PT916 GEO Homo sapiens GSE128230 8,264
MED12 leiomyoma PT1063 GEO Homo sapiens GSE128230 12,011
MED12 myometrium PT1063 GEO Homo sapiens GSE128230 19,387
MED12 myometrium PT916 GEO Homo sapiens GSE128230 51,878
MED12 myometrium PT967 GEO Homo sapiens GSE128230 19,159
MED12 myometrium PT886 GEO Homo sapiens GSE128230 37,952
MED12 myometrium PT848 GEO Homo sapiens GSE128230 4,780
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks