MED1

Information MED1

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Essential for embryogenesis, including development of the central nervous system, heart, liver and placenta and for erythropoiesis. Also required for normal transcriptional control of thyroid-stimulating hormone beta (TSHB) in the pituitary. Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (By similarity). {ECO:0000250|UniProtKB:Q15648, ECO:0000269|PubMed:10882104, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:14500757, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15150259, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:16137621, ECO:0000269|PubMed:17132730, ECO:0000269|PubMed:9325263}.(Source UnitProtKB).

Full Name

mediator complex subunit 1

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
75
Biotypes
23
Peaks
1,648,426
Non-redundant peaks
473,218

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
19014
Official Gene Name
Med1
JASPAR
MGI
MGI:1100846
Ensembl
ENSMUSG00000018160
UniProt
Q925J9
Genevisible
Q925J9
RefSeq
NM_134027
Aliases
AI480703; CRSP210; DRIP205; PBP; Pparbp; TRAP 220; TRAP220; TRIP-2; l11Jus15

External links
All peaks MED1
Download BED file
Non redundant peaks MED1
Download BED file
SEQUENCES MED1
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for MED1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
MED1 spleen GEO Mus musculus GSE78804 477
MED1 Th1 TBX21-KO GEO Mus musculus GSE62482 226
MED1 pancreas-cancer GEO Mus musculus GSE72069 12,913
MED1 liver 5AM GEO Mus musculus GSE104129 43,103
MED1 liver 5PM GEO Mus musculus GSE104129 44,640
MED1 liver GEO Mus musculus GSE128535 3,452
MED1 VSMC shNT GEO Mus musculus GSE112417 13,410
MED1 VSMC GEO Mus musculus GSE112417 952
MED1 thymocyte GEO Mus musculus GSE48763 1,897
MED1 pre-B-cell IKDN GEO Mus musculus GSE86897 14,915
MED1 BAT KO GEO Mus musculus GSE63965 1,597
MED1 mammary GEO Mus musculus GSE72724 12,537
MED1 EL4 GFP_RA GEO Mus musculus GSE62482 43,467
MED1 preadipocyte 4h GEO Mus musculus GSE95533 77,562
MED1 intestinal-villus-epithelial-cell WT GEO Mus musculus GSE98724 33,405
MED1 hematopoietic-progenitor IBET GEO Mus musculus GSE110896 16,872
MED1 hematopoietic-progenitor DMSO GEO Mus musculus GSE110896 12,464
MED1 hematopoietic-progenitor LSD1i GEO Mus musculus GSE110896 11,338
MED1 AML JQ1 GEO Mus musculus GSE74536 20,209
MED1 AML DMSO GEO Mus musculus GSE74536 32,537
MED1 skeletal-muscle quadricep GEO Mus musculus GSE123877 647
MED1 skeletal-muscle diaphragm GEO Mus musculus GSE123877 227
MED1 skeletal-muscle soleus GEO Mus musculus GSE123877 930
MED1 back-skin TAC GEO Mus musculus GSE61316 11,355
MED1 mESC siCtrl GEO Mus musculus GSE115340 20,588
MED1 mESC GEO Mus musculus GSE22562 1,468
MED1 mESC b_4OHT GEO Mus musculus GSE131926 53,714
MED1 mESC bethyl GEO Mus musculus GSE59569 5,385
MED1 mESC 2i GEO Mus musculus GSE88769 182
MED1 mESC GEO Mus musculus GSE59378 1,149
MED1 mESC DKO GEO Mus musculus GSE74055 1,358
MED1 mESC GEO Mus musculus GSE88769 217
MED1 mESC siEsrrb GEO Mus musculus GSE115340 38,656
MED1 mESC GEO Mus musculus GSE80049 1,441
MED1 mESC 2i-JQ1 GEO Mus musculus GSE88769 1,660
MED1 mESC JQ1 GEO Mus musculus GSE88769 129
MED1 mESC GEO Mus musculus GSE129179 3,146
MED1 pro-B-cell GEO Mus musculus GSE42474 21,099
MED1 brown-preadipocyte D7 GEO Mus musculus GSE74189 2,093
MED1 brown-preadipocyte D3 GEO Mus musculus GSE74189 26,452
MED1 brown-preadipocyte D2 GEO Mus musculus GSE74189 6,504
MED1 brown-preadipocyte D0 GEO Mus musculus GSE74189 13,139
MED1 3T3-L1 Scr GEO Mus musculus GSE56872 78,737
MED1 3T3-L1 rosi GEO Mus musculus GSE56745 11,629
MED1 3T3-L1 GEO Mus musculus GSE56872 51,710
MED1 mammary-gland L10 GEO Mus musculus GSE115368 73,208
MED1 skeletal-muscle EDL GEO Mus musculus GSE123877 324
MED1 back-skin Tel-Bulge GEO Mus musculus GSE61316 552
MED1 Th1 GEO Mus musculus GSE62482 2,090
MED1 BAT GEO Mus musculus GSE63965 2,282
MED1 mammary-gland P13 GEO Mus musculus GSE74826 2,228
MED1 mammary-gland L1 GEO Mus musculus GSE74826 22,519
MED1 preadipocyte D4 GEO Mus musculus GSE95533 46,114
MED1 preadipocyte D2 GEO Mus musculus GSE95533 69,771
MED1 preadipocyte D0 GEO Mus musculus GSE95533 29,850
MED1 preadipocyte D7 GEO Mus musculus GSE95533 44,988
MED1 MEF GEO Mus musculus GSE22562 5,917
MED1 cortical-neuron Reelin GEO Mus musculus GSE66701 265
MED1 liver 5PM_NR1D1-KO GEO Mus musculus GSE104129 41,786
MED1 liver T3 GEO Mus musculus GSE128535 10,346
MED1 AML RN2 GEO Mus musculus GSE74536 65,742
MED1 mESC a_4OHT GEO Mus musculus GSE131926 47,272
MED1 mESC OSKM4 GEO Mus musculus GSE59569 21,749
MED1 mESC OSKM8 GEO Mus musculus GSE59569 23,477
MED1 mESC SNEL3 GEO Mus musculus GSE59569 58,460
MED1 mESC SNEL4 GEO Mus musculus GSE59569 21,751
MED1 mESC GEO Mus musculus GSE42474 8,651
MED1 mESC 48h GEO Mus musculus GSE42474 10,148
MED1 mESC sc-5334 GEO Mus musculus GSE59569 7,908
MED1 mESC a GEO Mus musculus GSE131926 43,390
MED1 mESC b GEO Mus musculus GSE131926 42,288
MED1 EL4 RA GEO Mus musculus GSE62482 43,519
MED1 3T3-L1 no-DEX GEO Mus musculus GSE56872 78,241
MED1 3T3-L1 CEBPB GEO Mus musculus GSE56872 67,240
MED1 3T3-L1 GEO Mus musculus GSE56745 4,762
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks