MED23

Information MED23

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Also required for transcriptional activation subsequent to the assembly of the pre-initiation complex. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000250, ECO:0000269|PubMed:11934987, ECO:0000269|PubMed:14759369, ECO:0000269|PubMed:15542641, ECO:0000269|PubMed:15749018}.

Full Name

mediator complex subunit 23

Source UniprotKB

Species

Mus musculus [tax_id: 10090]

Genome

mm10

ReMap Statistics

Datasets
3
Biotypes
2
Peaks
6,299
Non-redundant peaks
6,265

TF Classification

Familly
NA
Sub Familly
NA

Source JASPAR

External IDs

NCBI Gene
70208
Official Gene Name
Med23
JASPAR
MGI
MGI:1917458
Ensembl
ENSMUSG00000019984
UniProt
Q80YQ2
Genevisible
Q80YQ2
RefSeq
NM_027347
Aliases
3000002A17Rik; Crsp3; ESTM7; Sur2; X83317
All peaks MED23
Download BED file
Non redundant peaks MED23
Download BED file
SEQUENCES MED23
Download FASTA file
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Datasets Table for MED23

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
MED23 cortical-neuron Reelin GEO Mus musculus GSE66701 284
MED23 mESC DKO GEO Mus musculus GSE74055 164
MED23 mESC GEO Mus musculus GSE74055 5,851
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks