MEN1
Information MEN1
- Description
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression (By similarity). May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair. {ECO:0000250|UniProtKB:O00255, ECO:0000269|PubMed:16415155}.(Source UnitProtKB).
- Full Name
multiple endocrine neoplasia 1
Source UniprotKB
- Species
Mus musculus [tax_id: 10090]
- Genome
mm10
ReMap Statistics
- Datasets
- 6
- Biotypes
- 4
- Peaks
- 128,066
- Non-redundant peaks
- 98,986
TF Classification
- Familly
- NA
- Sub Familly
- NA
Source JASPAR
External IDs
- NCBI Gene
- 17283
- Official Gene Name
- Men1
- JASPAR
- MGI
- MGI:1316736
- Ensembl
- ENSMUSG00000024947
- UniProt
- O88559
- Genevisible
- O88559
- RefSeq
- NM_008583
- Aliases
- AW045611; menin
Datasets Table for MEN1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| MEN1 | CD4 | secondary | GEO | Mus musculus | GSE53831 | 22,329 | ||
| MEN1 | C2C12 | MB | GEO | Mus musculus | GSE50590 | 24,095 | ||
| MEN1 | Th2 | 1st-gen | GEO | Mus musculus | GSE99259 | 26,664 | ||
| MEN1 | Th2 | 3rd-gen | GEO | Mus musculus | GSE99259 | 22,989 | ||
| MEN1 | CD4 | primary | GEO | Mus musculus | GSE53831 | 28,178 | ||
| MEN1 | MEF | KO | GEO | Mus musculus | GSE120635 | 3,811 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |