MTA1
Information MTA1
- Description
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
- Full Name
metastasis associated 1
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 3
- Biotypes
- 3
- Peaks
- 106,986
- Non-redundant peaks
- 93,994
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
External IDs
- NCBI Gene
- 9112
- Official Gene Name
- MTA1
- JASPAR
- Ensembl
- ENSG00000182979
- UniProt
- Q13330
- Genevisible
- Q13330
- RefSeq
- NM_001203258
- Aliases
Datasets Table for MTA1
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
MTA1 | Hep-G2 | ENCODE | Homo sapiens | ENCSR983KRB | 66,487 | |||
MTA1 | MCF-7 | ENCODE | Homo sapiens | ENCSR348JOJ | 15,958 | |||
MTA1 | K-562 | ENCODE | Homo sapiens | ENCSR807BGP | 24,541 | |||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |