MTA1

Information MTA1

Description

This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Full Name

metastasis associated 1

Source NCBI

Species

Homo sapiens [tax_id: 9606]

Genome

hg38

ReMap Statistics

Datasets
3
Biotypes
3
Peaks
106,986
Non-redundant peaks
93,994

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

NCBI Gene
9112
Official Gene Name
MTA1
JASPAR
Ensembl
ENSG00000182979
UniProt
Q13330
Genevisible
Q13330
RefSeq
NM_001203258
Aliases
All peaks MTA1
Download BED file
Non redundant peaks MTA1
Download BED file
SEQUENCES MTA1
Download FASTA file
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Datasets Table for MTA1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
MTA1 Hep-G2 ENCODE Homo sapiens ENCSR983KRB 66,487
MTA1 MCF-7 ENCODE Homo sapiens ENCSR348JOJ 15,958
MTA1 K-562 ENCODE Homo sapiens ENCSR807BGP 24,541
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks