MTF2

Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:20144788, PubMed:21367819, PubMed:21059868, PubMed:23104054, PubMed:22438827). Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (PubMed:20144788). Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (PubMed:21367819). Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (PubMed:21059868). In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (PubMed:21059868). Binds to the metal-regulating-element (MRE) of MT1A gene promoter (PubMed:7772254). {ECO:0000269|PubMed:20144788, ECO:0000269|PubMed:21059868, ECO:0000269|PubMed:21367819, ECO:0000269|PubMed:22438827, ECO:0000269|PubMed:23104054, ECO:0000269|PubMed:7772254}.(Source UnitProtKB).

metal response element binding transcription factor 2

Source UniprotKB

Mus musculus [tax_id: 10090]

mm10