MXI1
Information MXI1
- Description
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]
- Full Name
MAX interactor 1, dimerization protein
Source NCBI
- Species
Homo sapiens [tax_id: 9606]
- Genome
hg38
ReMap Statistics
- Datasets
- 8
- Biotypes
- 8
- Peaks
- 172,578
- Non-redundant peaks
- 91,912
TF Classification
- Super Class
- Basic domains
- Class
- Basic helix-loop-helix factors (bHLH)
- Familly
- bHLH-ZIP factors
- Sub Familly
- Mad-like factors
Source TFClass
External IDs
- NCBI Gene
- 4601
- Official Gene Name
- MXI1
- JASPAR
- MA1108
- Ensembl
- ENSG00000119950
- UniProt
- P50539
- Genevisible
- P50539
- RefSeq
- NM_001008541
- Aliases
- MAD2; MXD2; MXI; bHLHc11
Datasets Table for MXI1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| MXI1 | WA01 | ENCODE | Homo sapiens | ENCSR000EBR | 11,430 | |||
| MXI1 | SK-N-SH | ENCODE | Homo sapiens | ENCSR000EIA | 45,067 | |||
| MXI1 | K-562 | ENCODE | Homo sapiens | ENCSR000EGZ | 11,785 | |||
| MXI1 | IMR-90 | ENCODE | Homo sapiens | ENCSR000EFE | 40,944 | |||
| MXI1 | Hep-G2 | ENCODE | Homo sapiens | ENCSR000EDU | 18,671 | |||
| MXI1 | neural | ENCODE | Homo sapiens | ENCSR934NHU | 16,559 | |||
| MXI1 | GM12878 | ENCODE | Homo sapiens | ENCSR000DZI | 5,875 | |||
| MXI1 | HeLa-S3 | ENCODE | Homo sapiens | ENCSR000ECU | 22,247 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |